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Periventricular Heterotopia

Scott Loeb DO
Medically reviewed by Dr. Loeb
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Scott Loeb DO
Medically reviewed by Dr. Loeb

Periventricular nodular heterotopia refers to chronic neurological disorders caused by inheritance factors. This disorder is characteristic of impaired nerve cells, dysfunctional to migrate and form naturally proportional dimensions of the gray matter. It starts to develop during the second trimester of fetal development.


According to clinical research, periventricular heterotopia results from gene mutations. In particular, deteriorated FLNA gene responsible for producing protein filamin A provokes fatal consequences for newborns. Baby girls born with heterotopia positive factors more frequently suffer from epileptic seizures and other related neurological disturbances in teenagers and adults. Baby boys represent a risky group if they are diagnosed with heterotopia preconditions when their mothers have serious pregnancy issues. Men with in-birth heterotopia symptoms often face risks of long-life disabilities or fatal consequences of the labor proceedings.


To mitigate the risks of this aggressive neurological disease progression, you need to implement preventive measures, including:

  • consulting specialists in case of any related trigger existence;
  • following medical prescriptions to treat the evident symptoms;
  • adhering to active and healthy lifestyle attributes like physical exercises, work-and-rest schedule, and dietary formula improvements.


Symptoms of Periventricular Heterotopia

Signs of periventricular nodular heterotopia are typical for ailments with a deteriorated neurological system and encompass classified groups:

  • mental disorders;
  • physical abnormalities;
  • emotional disbalances.

Symptoms of periventricular heterotopia

However, only qualified neurologists could determine a correct diagnosis upon the proper clinical tests, surveys, and physical examinations. All medical investigation manipulations are directed to learn the following signals of neuronal heterotopia factors:


  • Mental disorders. Patients with periventricular heterotopia often refer to epilepsy positive groups due to periodic seizures. In particular, episodes appear upon the diagnosis of drug-resistant epilepsy. However, these convulsive attacks differ from epileptic or other dementia symptoms because of their simple triggers;
  • Physical abnormalities. All patients complain of respiratory and cardiovascular dysfunctions, which inexperienced specialists could qualify as stressful situations or anatomical lung and heart problems. Moreover, this heterotopia category is characteristic of head disproportions leading to brain malformations, development delays, and weak immune reactions to infectious diseases;
  • Emotional disbalances. Depression and anxiety accompany many neurological ailments, and heterotopia is not an exclusion. Moreover, people living with neuronal heterotopia could feel frustration and emotional restlessness. All emotional factors could signify a more profound neurological disorder and need more professional analysis.


In addition to neurological-related symptoms, you may observe psychosomatic signs like insomnia, headaches, and erectile dysfunctions. The frequency of symptoms could increase during the teenage period, when patients are subject to hormonal changes.


Causes of Periventricular Heterotopia

The main causes of neuronal heterotopia could be grouped into:

  • genetic;
  • gender;
  • incorrect neurological diagnosis.

Causes of periventricular heterotopia

Neurological-associated cues cause periventricular heterotopia. However, this heterotopia case requires more clinical surveys. You may distinguish several groups of high risky triggers:


  • Genetic. The leading factor is particular gene mutations that determine normal brain development. Although people with heterotopia abnormalities do not demonstrate deteriorated intelligence, their physiological and mental parameters identify severe disabilities;
  • Gender. Mutations with the X chromosome mean this disorder is equally typical for males and females. However, women do not notice crucial mental changes except involuntary seizures. Men always feel more severe dysfunctions. According to death statistics, males with neuronal heterotopia could face fatal consequences in the labour;
  • Incorrect neurological diagnosis. Improper diagnostic and epilepsy-related treatment could provoke respective heterotopia seizures and deteriorate overall health indicators. In particular, convulsive attacks are caused by epilepsy-recommended medication. Some chemical substances could provoke side effects and demonstrate involuntary shaking.


Is Heterotopia a Genetic Disorder?

The periventricular nodular heterotopia has a completely genetic nature. Neurologists still discuss factors that provoke gene mutations and deteriorate gray matter function. Therefore, inheritance-related triggers include the following risky genes:

  • FLNA genes. Mutations of this gene imply disabilities of the nerve cells to create standard shapes and motions, leading to brain development delays. The impaired FLNA gene could be hardly renovated without qualified treatment recommendations;
  • ARFGEF2 gene. The unnatural changes of this gene provoke neurological disorders of nerve movement instructions. In particular, neurons lose their abilities to control migration processes for comprehensive gray matter development;
  • Chromosome 5. The rare cases of chromosome 5 mutations also demonstrate conditions that create a suitable environment for neuronal heterotopia progress.


To reduce the chances of diversified gene mutations, potential patients should plan pregnancy properly and visit neurologists, especially if their family members have been diagnosed with neurological impairments.


Diagnosis of Periventricular Heterotopia

Diagnosis of periventricular heterotopia

The diagnostic methods allowed for this heterotopia category comprise:

  • physical examination;
  • blood tests;
  • magnetic resonance imaging (MRI);
  • PET scan;
  • EEG scan;
  • ECG diagnostics.


Before neurologists confirm a periventricular heterotopia diagnosis, they conduct several diagnostic methods, including:

  • Physical examination. Patients are examined to compare actual physical parameters with regulatory ones. Any omissions or inequalities should signalize neurological or anatomical abnormalities, which could have numerous adverse consequences;
  • Blood tests. Neurologists check the blood test fact-findings to exclude other diseases or disorders which could provoke neuron impairments and other dysfunctions of the nerve system. Also, the blood tests discover the patient’s overall health picture and the existence of accompanying ailments;
  • Magnetic resonance imaging (MRI). The best diagnostic medium to identify in-birth deterioration in neuron ties. In other words, MRI studies provide a comprehensive picture of seizure-stimulating factors and processes accompanied by involuntary convulsions. In addition, this brain screening method specifies single or multiple nodules of gray matter adjacent to the lateral ventricular walls which become primary signals of periventricular heterotopia;
  • PET scan. If a patient’s clinical surveys demonstrate cancer or heart disease risks, neurologists could use PET scanning to exclude all possible cases. The PET scan provides the comprehensive screening of all patient systems and nerves responsible for the essential living functions;
  • EEG scan. Due to the EEG technique, neurologists record brain activities and detect calm and active phases related to epilepsy seizures. This method could become an accompanying measure to MRI surveys;
  • ECG diagnostics. Along with EEG surveys, ECG results help exclude cardiovascular problems resulting from progressive neuronal heterotopia disturbances or in-birth heart disorders.


Treatment of Periventricular Heterotopia

The relief approaches which eliminate signs of periventricular nodular heterotopia foresee surgery manipulations and suspend the further deterioration processes. The surgical manipulations are safe for patients because they use laser and radio magnetic technologies in order to remove the leisure.

Treatment of periventricular heterotopia

The post-surgical period includes several recovery methods to support normal living functions:

  • Medication therapy. Patients could be prescribed to take anti-seizure medications and sedative products, which eliminate anxiety and depression feelings. Also, vitamins like group B and Omega 3s would be valuable to stimulate immune reactions and improve cognitive functions;
  • Physical therapy. These methods comprise activities dedicated to strengthening muscle and body constitution in resistance to deterioration progress and actions aimed at overcoming developmental delays. Along with other neurological disorders, yoga and aerobic exercises should be combined with chess classes to provide harmonic physical growth;
  • Gastronomic therapy. Special dietary formulas consisting of vegetables, fruits, and berries are recommended for patients with neurological disabilities. Organic lean protein-contained products are also approved for people diagnosed with neuronal heterotopia. To this end, neurologists suggest adjusting meal habits and excluding hazardous foods like gluten, sugar, trans fats, and others;
  • Mental health therapy. Meditation practices and psychological training could become a part of the post-surgical treatment complex to rehabilitate social life activities. In addition, patients should learn techniques to get rid of seizures and anxiety states by themselves. Outdoor activities provide maximum positive effects on mental health recovery. Some specialists highlight the incredible results of art therapy in improving cognitive and emotional functions.


Each therapy program built for a particular neurological disorder requires a proper approach and detailed analysis of external and internal factors which stimulate dysfunctions. As periventricular nodular heterotopia refers to in-birth deterioration, you could hardly recover completely. However, the medication methods eliminate the symptoms and support normal living functions. Therefore, success for the relief formula equals in-time and adequate diagnostic mediums.


Regular Neurological Diagnosis Reduce Risks of Fatal Consequences 

Any seizure should not be neglected if a patient notices convulsive periodical attacks. Also, the pre-pregnancy period is critical for careful diagnostics and inclusion of all possible risks for babies. Therefore, everyone should call for a qualified neurological consultation to eliminate the chances of any deterioration progress. Our Lone Star Neurology team can investigate the patient’s medical history and determine the correct diagnosis upon cutting-edge professional clinical surveys and tests.



  • What is periventricular nodular heterotopia?

Periventricular nodular heterotopia is a neurological disorder affecting the brain’s gray matter and leading to severe neurological dysfunctions. This disease refers to chronic and originates from gene mutations. Moreover, irreversible impairments start during the second trimester and require proper supervision by a qualified specialist.

  • How is periventricular heterotopia treated?

Periventricular heterotopia has only one appropriate way of treatment therapy – surgery. Using lasers and radio magnetic technologies makes this procedure entirely safe for patients. Upon surgical manipulations, patients are recommended to follow rehabilitation therapies acceptable to neurological disorders. Physical exercises, dietary formulas, and mental health improvement methods are must-have activities to strengthen impaired neurological functions.

  • What is an example of heterotopia?

A traditional neuronal heterotopia includes the following symptoms:

– epilepsy-related seizures, which appear in teenagers age;

– respiratory and cardiovascular dysfunctions;

– mental impairments like brain development delays and abnormal physical dimensions of the head.


  • Is periventricular heterotopia an inherited disease?

Clinical research does not provide reasonable explanations about inheritance evidence of periventricular heterotopia: from positive-diagnosed patients to future generations. However, this ailment qualifies as a neurological disorder and, therefore, could provoke bad reactions in anatomical features of neurons.

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Edward Medina
Edward Medina
15:34 30 Jun 22
Just such an amazing staff that makes you feel like part of their family. I’ve been going there for over 5 years now... and each visit I get the very best care and treatments that I have ever received in the 20+ years that I’ve been dealing with severe debilitating migraines. Since i started seeing them the number of my migraines has dropped from 15-20 a month to 2-3 every 3 month. I highly recommend them …they will change your life!read more
Daneisha Johnson
Daneisha Johnson
22:20 19 May 22
Dr. Askari was very kind and explained everything so I could understand. The other staff were nice as well. I would... have gave 5 stars but I was a little taken aback when I checked in and had to pay 600.00 upfront. I think that should have been discussed in a appointment confirmation call or email just so I could have been more
Jean Cooper
Jean Cooper
16:54 29 Apr 22
I love the office staff they are friendly and very helpful. Dr. JODIE is very caring and understanding to your needs... and wants to help you. I will go back. would recommend Dr. Dr. Jodie to other Patients in a heart beat. The team works well more
Linda M
Linda M
19:40 02 Apr 22
I was obviously stressed, needing to see a neurologist. The staff was so patient and Dr. Ansari was so kind. At one... point he told me to relax, we have time, when I was relaying my history of my condition. That helped ease my stress. I have seen 3 other neurologists and he was the only one who performed any assessment tests on my cognitive and physical skills. At one point I couldn't complete two assessments and got upset and cried. I was told, it's OK. That's why you're here. I was truly impressed, and super pleased with the whole experience!read more
Leslie Durham
Leslie Durham
15:05 01 Apr 22
I've been coming here for about 5 years. The staff are ALWAYS friendly and knowledgeable. The Doctors are the absolute... best!! Jodie Moore is always in such a great mood which is a plus when you are already stressed. Highly recommendedread more
Monica Del Bosque
Monica Del Bosque
14:13 25 Mar 22
Since my first post my thoughts have changed here. It's unfortunate. My doctor and PA were great, but the office staff... is horrible. They never call you back when they say they will, they misinform you, they cause you too much stress wondering what's going on, they don't keep you posted. They never answer the phone. At this point I've left four messages in the last week, and I have sent three messages. Twice from their portal and one direct email. No response. My appointment is on Monday morning at 8:30am, no confirmation on my insurance and what's going on. What the heck is going on, this is ridiculous!I've given up... the stress her office staff has put me through is just not worth it. You can do so much better, please clean house, either change out your office staff, or find a way for them to be more efficient please. You have to do something. This is not how you want to run your practice. It leaves a very bad impression on your more
Ron Buckholz
Ron Buckholz
23:32 23 Mar 22
I was actually pleasantly surprised with this visit! It took me a long time to get the appointment scheduled because no... one answers your phones EVER! After a month, I finally got in, and your staff was warm, friendly, and I was totally impressed! I feel like you will take care of my needs!read more
Steve Nabavi
Steve Nabavi
16:28 16 Mar 22
It was a nice visit. Happy staff doing all they can do to comfort the patients in a very calming environment. You ask... me they are earned a big gold star on the fridge. My only complaint they didn't give me any more
Katie Lewis
Katie Lewis
16:10 10 Feb 22
Had very positive appointments with Jodie and Dr. Sheth for my migraine care. Jodie was so fast with the injections and... has so much valuable info. I started to feel light headed during checkout and the staff was SO helpful—giving me a chair, water, and taking me into a private room until I felt better. Highly recommend this practice for migraine patients, they know what they’re doing!!read more
Joshua Martinez
Joshua Martinez
16:02 10 Dec 21
I was scheduled to be checked and just want to say that the staff was fantastic. They were kind and helpful. I was... asked many questions related to what was going on and not once did I feel as though I was being brushed off. The front desk staff was especially great in assisting me. I'm scheduled to go back for a mri and am glad that I'll be going more
Isabel Ivy
Isabel Ivy
21:42 03 Nov 21
I had such a good experience with Lone Star Neurology, Brent my MRI Tech was so awesome and made sure I was very... comfortable during the appointment. He gave me ear plugs, a pillow, leg support and blanket, easiest MRI ever lol 🤣 My 72 hour EEG nurse Amanda was also so awesome. She made sure I was take care of over the 3 days and took her time with the electrodes to make sure it was comfortable for me! Paige was also a huge help in answering all my questions when it came to my test results, and letting me know her honest opinions about how I should go forth with my more
Leslie Luce
Leslie Luce
17:37 20 Oct 21
The professionalism and want to help attitude of this office was present from the moment I contacted them. The follow... up and follow through as well as their willingness to find a way to schedule my dad was above and beyond. We visited two offices in the same day with the same experience. I am appreciative of this—we spend a lot of time with doctors and this was top notch start to more
robert Parker
robert Parker
16:38 16 Apr 21
I love going to this office. The staff is friendly and helpful. The doctor is great. I am getting the best... neurological tests and treatment I have ever had. The only reason I did not give them a 5 star rating is because it is impossible to reach a live person at the office to reschedule appointments. Every time I have tried to get through to the office it says all people are busy and I am sent to a voicemail. If they could get their phone answering fixed, I would give them a strong 5 more
MaryAnn Hornbaker
MaryAnn Hornbaker
00:26 25 Feb 21
Dr. Harney is an excellent Dr. I found him friendly , personable and thorough. I evidently am an unusual case. ... Therefore he spent a Hugh amount of time educating me. He even gave me literature to further explain my condition and how to follow up. This is something you rarely get from your doctors. So I am more than please with my doctor and his more
Roger Arguello
Roger Arguello
03:05 29 Jan 21
Always courteous, professional. The staff is very friendly and always work with you to find the best appointment time.... The care team has been great. Always taking the time to listen to your concerns and to find the best more
Margaret Rowland
Margaret Rowland
01:12 27 Jan 21
I have been a patient at Lone Star Neurology for several years. Now both my adult daughters also are patients there. I... love Jodie. She is always so prompt whether it is a teleamed call are a visit in the office. She takes the time to explain everything to me and answers all my questions. I am so blessed to have Jodie as my more
Susan Miller
Susan Miller
03:01 13 Jan 21
My husband had an accident 5 years ago and Lone Star Neurology has been such a blessing to us with my husbands care.... Jodie Moore is his provider and she is amazing! Jodie is very knowledgeable, caring, and thorough. She takes her time with you, making sure your needs are met and she is happy to answer any questions you may have. Lone Star Neurology’s patients are very lucky to have Jodie providing their care. Thank you Lone Star Neurology and especially Jodie for everything you have done for us. Jodie, you are the best!read more
Windalyn C
Windalyn C
01:32 09 Jan 21
Jodie is wonderful. She is very caring and knowledgeable. I have been to over a dozen neurologists, and none were able... to help me as much as they have here. Thanks!read more
Katie Kordel
Katie Kordel
00:40 09 Jan 21
Jodi Moore, nurse practitioner, is amazing. I have suffered from frequent, debilitating headaches for almost 20 years.... She has provided the best proactive and responsive care I have ever received. My quality of life has been greatly improved by her caring approach and tenacity in finding more
Ellie Natsis
Ellie Natsis
15:41 07 Jan 21
I have had the best experience at this neurologist's office! For over a year I have been receiving iv treatments here... each month and my nurse, Bobbie is beyond wonderful!! She's so attentive, knowledgeable, caring, and detail oriented. She makes an otherwise uncomfortable experience much more pleasant and definitely puts me at ease! She also helps me with my insurance,ordering this specialty medication and dealing with the ordering process which is no easy feat.Needless to say, she goes above a beyond in every way and I'm so grateful to this office and to Bobbie for all they do for me!read more
Matt Morris
Matt Morris
15:39 07 Jan 21
Let me start by saying that I have been coming here for years. Due to my autoimmune disease, I am in this office... once every three weeks for multiple hours at a time. The office is very clean and the staff very friendly. My only complaint would be there communication via phone. They aren't the best at responding if you leave a voicemail and expect a call back. I understand that this is prob just due to the sheer number of alls they receive daily. What I can say I like the best about the office are the people. Bobby who handles my infusions is great. I never have any issues with her setting up my infusions. She is very quick to reply to messages sent via text and if she were to leave then my whole opinion of the office may change. I also enjoy people like Matt, Lauren, and Jodi. I appreciate all that they do for me and without this team I'm not sure I would be as happy as I am to visit the office as frequently as I have to. Please ensure that these folks are recognized as they are what makes my visit to this office so tolerable :).read more
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