Mon - Fri: 8:00AM - 5:00PM
Monday – Friday8:00AM - 5:00PM
Saturday Open for MRI
Sunday Closed
Migraine treatment same day as your first appointment.
or
Visit our Healow Portal
Visit our Healow Portal Call 214-619-1910
CALL 214-619-1910

What is Neurodegenerative Disease?

Ramin Ansari tx neurologist
Medically reviewed by Ramin Ansari
Ramin Ansari tx neurologist
Medically reviewed by Ramin Ansari

Due to the increase in life expectancy, neurodegenerative diseases are increasingly common worldwide. The cause of neuronal death, which causes neurodegenerative diseases and leads to various neurological symptoms, primarily dementia, and impaired movement, is unknown. Symptoms in neurodegenerative diseases depend on which part of the central nervous system is affected. Modern treatment methods are symptomatic and aimed at increasing the activity of surviving neurons to minimize the clinical manifestations of the degenerative process.

Neurodegenerative diseases unite a large group of diseases of the human nervous system, the cause of which is the massive death of certain neurons; moreover, both internal and external factors of infection, intoxication, physical trauma, metabolic disorders, etc. Cases of hereditary predisposition to the emergence of this group have been noticed. Moreover, certain types of neurons often die irrevocably without affecting other parts of the nervous tissue.

Most often, such diseases appear in older people. Among neurodegenerative diseases, the most common are Parkinson’s disease, Alzheimer’s, cerebellar degeneration, spinal amyotrophies, etc.

Mechanisms of development of neurodegenerative diseases

The pathophysiological mechanisms of neurodegenerative diseases include the synthesis and aggregation of proteins with a pathological confirmation; this, in turn, triggers a cascade of immune and metabolic disorders, accumulation of metals in the central nervous system, impaired energy metabolism of cells, enzyme deficiency, etc. At the same time, genetic factors play a significant role in the development of the neurodegenerative process. There are monogenic neurodegenerative diseases (for example, Huntington’s disease, spinal amyotrophies, several variants of spinocerebellar ataxias, Wilson’s disease, monogenic variants of Parkinson’s disease, spastic paraplegia, paroxysmal dyskinesias, etc.). And there are also diseases that develop as a result of disorders in the functioning of whole ensembles with the action of unfavorable environmental factors (idiopathic Parkinson’s disease, atypical parkinsonism, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, etc.). At the same time, it is essential to remember that the absence of a burdened family history of the neurodegenerative disease does not exclude the presence of a genetic predisposition to its development.

Diagnosis of neurodegenerative diseases consists of a comprehensive assessment of the clinical picture, the nature of the onset and progression of the disease, instrumental laboratory studies, and neuroimaging data. Methods of genetic testing take a special place in the diagnostic process. Given the complex relationship between the genotype and phenotype of the disease, genetic testing is often not limited to analyzing one or two genes. In complex diagnostic cases, to reduce the cost and increase the efficiency of diagnostic search, the method of high-throughput sequencing is widely used, which allows analyzing up to several hundred genes at once.

Environmental health sciences specialists focus on improving public health by eliminating environmental risk factors and identifying the relationships and health risks of the physical environment.

Neurodegenerative diseases of the central nervous system

Neurodegenerative diseases of the central nervous system

Neurodegenerative diseases are a conditionally isolated, heterogeneous group of relatively slow developing diseases with a predominant lesion of the gray matter of the central nervous system, and in most cases, characterized by the formation of abnormal cellular and/or extracellular inclusions (deposits) with subsequent death of neurons by the mechanism of apoptosis.

Unfortunately, for most neurodegenerative diseases, there are no radical methods of treatment that would completely stop the pathological process and ensure complete recovery. Therefore, early diagnosis of the disease and a timely start to treatment plays an essential role in influencing the course of the disease and improving the patient’s quality of life.

Among the majority of currently available research methods, only MRI can help the clinician make the correct diagnosis.

Among neurodegenerative diseases, Alzheimer’s disease and Parkinson’s disease are most common in clinical practice.

Considering this fact, for reliable diagnosis and differential diagnosis of these pathological processes in MRI, additional programs have been developed that allow for a targeted assessment of the area of ​​interest.

  • Parkinson’s syndrome. Parkinsonism is a slowly progressive neurological syndrome characterized by resting tremor, muscle rigidity, and hypokinesia.

The cause of parkinsonism syndrome can be cerebral atherosclerosis, craniocerebral trauma, epidemic encephalitis, toxic and metabolic disorders, the use of several drugs, and tumors (secondary parkinsonism).

Moreover, true parkinsonism is distinguished as a consequence of Parkinson’s disease.

Pathogenetically, with this disease, degeneration, and death of dopaminergic pigmented (melanin-containing) neurons, gliosis of these nuclear groups, atrophy of the adjacent parts of the midbrain lining, secondary degeneration of dopaminergic and noradrenaline pathways occur. In the substantia nigra, the deposition of iron ions in high concentrations is determined.

That is why in MRI centers, to accurately differentiate between real Parkinson’s disease and Parkinson’s syndrome caused by other causes, special programs are used to specifically study the area of ​​the pathological process and assess the state of the midbrain nuclei.

In most examined patients with Parkinson’s disease, the disappearance of the normal decreased MR signal from the reticular part of the substantia nigra and red nuclei is noted.

In some patients, there is a fusion of normally hypointense zones into one due to iron deposition in the compact and reticular parts.

  • Alzheimer’s disease. This neurodegenerative disease is one of the leading causes of dementia in modern society and is a socially significant problem.

Clinically, it is slightly more common in women. It is manifested by a progressive decay of cognitive functions, among which memory impairments occupy the first place. Acute psychotic episodes of delirium, hallucinations, delirium are possible. Less common are hyperkinetic disorders and parkinsonism syndrome.

In Alzheimer’s disease, unlike all other neurodegenerative diseases, the maximum changes are found in the hippocampus.

That is why MRI centers use special high-resolution programs with a targeted examination of the temporal lobes for the most accurate study of the state of the hippocampus.

At the same time, asymmetric atrophy of the hippocampus with thinning of the cortex, widening of Bichat’s gaps on both sides, and the temporal horns of the lateral ventricles is determined on coronal tomograms with a targeted study of the temporal lobes. These changes are the earliest. Also, atrophy of the parietal and occipital lobes with the expansion of the subarachnoid spaces is revealed.

Thus, the emergence of MRI diagnostics using special programs for the targeted study of areas of interest greatly facilitated the diagnosis of neurodegenerative diseases and allowed clinicians to make a correct diagnosis at an earlier stage of the disease, to prescribe the necessary drugs in a timely manner, which means to improve the prognosis of the disease and the patient’s quality of life.

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading...
Lone Star Neurology
4.4
Based on 766 reviews
powered by Google
Edward Medina
Edward Medina
15:34 30 Jun 22
Just such an amazing staff that makes you feel like part of their family. I’ve been going there for over 5 years now... and each visit I get the very best care and treatments that I have ever received in the 20+ years that I’ve been dealing with severe debilitating migraines. Since i started seeing them the number of my migraines has dropped from 15-20 a month to 2-3 every 3 month. I highly recommend them …they will change your life!read more
Daneisha Johnson
Daneisha Johnson
22:20 19 May 22
Dr. Askari was very kind and explained everything so I could understand. The other staff were nice as well. I would... have gave 5 stars but I was a little taken aback when I checked in and had to pay 600.00 upfront. I think that should have been discussed in a appointment confirmation call or email just so I could have been prepared.read more
Jean Cooper
Jean Cooper
16:54 29 Apr 22
I love the office staff they are friendly and very helpful. Dr. JODIE is very caring and understanding to your needs... and wants to help you. I will go back. would recommend Dr. Dr. Jodie to other Patients in a heart beat. The team works well together.read more
Linda M
Linda M
19:40 02 Apr 22
I was obviously stressed, needing to see a neurologist. The staff was so patient and Dr. Ansari was so kind. At one... point he told me to relax, we have time, when I was relaying my history of my condition. That helped ease my stress. I have seen 3 other neurologists and he was the only one who performed any assessment tests on my cognitive and physical skills. At one point I couldn't complete two assessments and got upset and cried. I was told, it's OK. That's why you're here. I was truly impressed, and super pleased with the whole experience!read more
Leslie Durham
Leslie Durham
15:05 01 Apr 22
I've been coming here for about 5 years. The staff are ALWAYS friendly and knowledgeable. The Doctors are the absolute... best!! Jodie Moore is always in such a great mood which is a plus when you are already stressed. Highly recommendedread more
Monica Del Bosque
Monica Del Bosque
14:13 25 Mar 22
Since my first post my thoughts have changed here. It's unfortunate. My doctor and PA were great, but the office staff... is horrible. They never call you back when they say they will, they misinform you, they cause you too much stress wondering what's going on, they don't keep you posted. They never answer the phone. At this point I've left four messages in the last week, and I have sent three messages. Twice from their portal and one direct email. No response. My appointment is on Monday morning at 8:30am, no confirmation on my insurance and what's going on. What the heck is going on, this is ridiculous!I've given up... the stress her office staff has put me through is just not worth it. You can do so much better, please clean house, either change out your office staff, or find a way for them to be more efficient please. You have to do something. This is not how you want to run your practice. It leaves a very bad impression on your business.read more
Ron Buckholz
Ron Buckholz
23:32 23 Mar 22
I was actually pleasantly surprised with this visit! It took me a long time to get the appointment scheduled because no... one answers your phones EVER! After a month, I finally got in, and your staff was warm, friendly, and I was totally impressed! I feel like you will take care of my needs!read more
Steve Nabavi
Steve Nabavi
16:28 16 Mar 22
It was a nice visit. Happy staff doing all they can do to comfort the patients in a very calming environment. You ask... me they are earned a big gold star on the fridge. My only complaint they didn't give me any cookies.read more
Katie Lewis
Katie Lewis
16:10 10 Feb 22
Had very positive appointments with Jodie and Dr. Sheth for my migraine care. Jodie was so fast with the injections and... has so much valuable info. I started to feel light headed during checkout and the staff was SO helpful—giving me a chair, water, and taking me into a private room until I felt better. Highly recommend this practice for migraine patients, they know what they’re doing!!read more
Joshua Martinez
Joshua Martinez
16:02 10 Dec 21
I was scheduled to be checked and just want to say that the staff was fantastic. They were kind and helpful. I was... asked many questions related to what was going on and not once did I feel as though I was being brushed off. The front desk staff was especially great in assisting me. I'm scheduled to go back for a mri and am glad that I'll be going there.read more
Isabel Ivy
Isabel Ivy
21:42 03 Nov 21
I had such a good experience with Lone Star Neurology, Brent my MRI Tech was so awesome and made sure I was very... comfortable during the appointment. He gave me ear plugs, a pillow, leg support and blanket, easiest MRI ever lol 🤣 My 72 hour EEG nurse Amanda was also so awesome. She made sure I was take care of over the 3 days and took her time with the electrodes to make sure it was comfortable for me! Paige was also a huge help in answering all my questions when it came to my test results, and letting me know her honest opinions about how I should go forth with my treatment.read more
Leslie Luce
Leslie Luce
17:37 20 Oct 21
The professionalism and want to help attitude of this office was present from the moment I contacted them. The follow... up and follow through as well as their willingness to find a way to schedule my dad was above and beyond. We visited two offices in the same day with the same experience. I am appreciative of this—we spend a lot of time with doctors and this was top notch start to finish.read more
robert Parker
robert Parker
16:38 16 Apr 21
I love going to this office. The staff is friendly and helpful. The doctor is great. I am getting the best... neurological tests and treatment I have ever had. The only reason I did not give them a 5 star rating is because it is impossible to reach a live person at the office to reschedule appointments. Every time I have tried to get through to the office it says all people are busy and I am sent to a voicemail. If they could get their phone answering fixed, I would give them a strong 5 stars.read more
MaryAnn Hornbaker
MaryAnn Hornbaker
00:26 25 Feb 21
Dr. Harney is an excellent Dr. I found him friendly , personable and thorough. I evidently am an unusual case. ... Therefore he spent a Hugh amount of time educating me. He even gave me literature to further explain my condition and how to follow up. This is something you rarely get from your doctors. So I am more than please with my doctor and his staff.read more
Roger Arguello
Roger Arguello
03:05 29 Jan 21
Always courteous, professional. The staff is very friendly and always work with you to find the best appointment time.... The care team has been great. Always taking the time to listen to your concerns and to find the best treatment.read more
Margaret Rowland
Margaret Rowland
01:12 27 Jan 21
I have been a patient at Lone Star Neurology for several years. Now both my adult daughters also are patients there. I... love Jodie. She is always so prompt whether it is a teleamed call are a visit in the office. She takes the time to explain everything to me and answers all my questions. I am so blessed to have Jodie as my doctor.read more
Susan Miller
Susan Miller
03:01 13 Jan 21
My husband had an accident 5 years ago and Lone Star Neurology has been such a blessing to us with my husbands care.... Jodie Moore is his provider and she is amazing! Jodie is very knowledgeable, caring, and thorough. She takes her time with you, making sure your needs are met and she is happy to answer any questions you may have. Lone Star Neurology’s patients are very lucky to have Jodie providing their care. Thank you Lone Star Neurology and especially Jodie for everything you have done for us. Jodie, you are the best!read more
Windalyn C
Windalyn C
01:32 09 Jan 21
Jodie is wonderful. She is very caring and knowledgeable. I have been to over a dozen neurologists, and none were able... to help me as much as they have here. Thanks!read more
Katie Kordel
Katie Kordel
00:40 09 Jan 21
Jodi Moore, nurse practitioner, is amazing. I have suffered from frequent, debilitating headaches for almost 20 years.... She has provided the best proactive and responsive care I have ever received. My quality of life has been greatly improved by her caring approach and tenacity in finding solutions.read more
Ellie Natsis
Ellie Natsis
15:41 07 Jan 21
I have had the best experience at this neurologist's office! For over a year I have been receiving iv treatments here... each month and my nurse, Bobbie is beyond wonderful!! She's so attentive, knowledgeable, caring, and detail oriented. She makes an otherwise uncomfortable experience much more pleasant and definitely puts me at ease! She also helps me with my insurance,ordering this specialty medication and dealing with the ordering process which is no easy feat.Needless to say, she goes above a beyond in every way and I'm so grateful to this office and to Bobbie for all they do for me!read more
Matt Morris
Matt Morris
15:39 07 Jan 21
Let me start by saying that I have been coming here for years. Due to my autoimmune disease, I am in this office... once every three weeks for multiple hours at a time. The office is very clean and the staff very friendly. My only complaint would be there communication via phone. They aren't the best at responding if you leave a voicemail and expect a call back. I understand that this is prob just due to the sheer number of alls they receive daily. What I can say I like the best about the office are the people. Bobby who handles my infusions is great. I never have any issues with her setting up my infusions. She is very quick to reply to messages sent via text and if she were to leave then my whole opinion of the office may change. I also enjoy people like Matt, Lauren, and Jodi. I appreciate all that they do for me and without this team I'm not sure I would be as happy as I am to visit the office as frequently as I have to. Please ensure that these folks are recognized as they are what makes my visit to this office so tolerable :).read more
Next Reviews
js_loader

Please, leave your review

Write a comment: