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Top 10 Muscle Diseases List: Symptoms & Treatments

Sajish Jacob
Medically reviewed by Sajish Jacob
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Sajish Jacob
Medically reviewed by Sajish Jacob


Muscular Diseases: List

Muscle pathologies pose a severe danger to the entire body. In the absence of competent therapy, they are fraught with disability. Such diseases significantly impair the quality of life. They progress quickly, leaving irreparable consequences. It is essential to learn to recognize their signs in time. You also need to familiarize yourself with modern treatment methods. The sooner you start therapy, the higher the chances of improving your quality of life. Most of these pathologies are incurable. Let’s dive into the top 10 muscle diseases list. This article has provided their characteristic features and effective treatment options.

Each disorder presents its own set of challenges and considerations. Let’s shed light on these conditions. In such a way, we aim to empower individuals and their loved ones with knowledge. It can facilitate informed decision-making and enhance overall well-being. Join us as we explore the complexities of muscle illnesses. We navigate the area of manifestations, diagnosis, and treatment strategies.

10 Muscular Diseases: List

Muscular Diseases

Ten muscular skeleton illnesses vary widely in their causes, severity, and progression. They all involve dysfunction of the muscular system. Seeking early diagnosis and appropriate treatment is essential. It helps with managing symptoms and improving the quality of life. This is vital for individuals affected by these muscular diseases. Here are 10 muscular diseases that can affect individuals, each with its signs and treatment approaches.

Muscular Dystrophy

This is a group of genetic diseases. They are usually characterized by progressive weakness and degeneration of the muscles. Duchenne muscular dystrophy is one of the most common forms.

Myasthenia Gravis

This autoimmune disorder leads to muscle weakness and fatigue. It is mainly in the muscles that control eye and eyelid movement, facial expression, chewing, swallowing, and talking.

Amyotrophic Lateral Sclerosis (ALS)

It is also known as Lou Gehrig’s disease. ALS is a progressive neurodegenerative disease. It affects nerve cells in the brain and spinal cord, leading to loss of muscle control and eventual paralysis.

Spinal Muscular Atrophy (SMA)

SMA is one of the most rare neuromuscular diseases listed. It is generally characterized by losing spinal cord and brainstem motor neurons. This is leading to muscle weakness and atrophy.


This is an illness which is usually caused by inflammation. It causes muscle weakness, tenderness, and inflammation.


Unlike polymyositis, dermatomyositis is also an inflammatory muscle disease. It also involves skin rash.

Myotonic Dystrophy

Such a genetic disorder is usually characterized by progressive muscle wasting. Also, among the signs are weakness and myotonia (prolonged muscle contractions).

Facioscapulohumeral Muscular Dystrophy (FSHD)

FSHD is a genetic disorder. It causes progressive weakness and muscle wasting in the face, shoulders, and upper arms.

Limb-Girdle Muscular Dystrophy

This is a group of genetic disorders. They primarily affect the muscles around the hips and shoulders. It leads to progressive muscle weakness and wasting.

Mitochondrial Myopathy

This is a group of neuromuscular diseases. Defects in the mitochondria usually cause it. It results in muscle weakness, exercise intolerance, and other symptoms.

Rare Muscle Diseases List in Adults

In adults, encountering rare muscle diseases list presents unique challenges. They are due to their uncommon occurrence and often a complex diagnostic process. These conditions, though infrequent, can significantly impact a person’s quality of life. They cause debilitating symptoms and require specialized care.

Understanding and identifying these rare muscle illnesses is essential. It helps for timely intervention and effective management. We’ll explore a curated list of such conditions. We shed light on their signs, diagnostic criteria, and treatment options.

Limb-Girdle Muscular Dystrophy (LGMD)

LGMD is a group of genetic muscle disorders that primarily affect the muscles around the shoulders and hips. It is famous for the limb-girdle muscles. It is usually characterized by progressive muscle weakness and wasting. This leads to difficulties with mobility and everyday activities. LGMD can present in adulthood, although onset may occur at any age, and its severity can vary widely among affected individuals. Signs often include difficulty raising the arms, climbing stairs, or walking, as well as muscle pain and fatigue. 

Facioscapulohumeral Muscular Dystrophy (FSHD)

This rare muscle disease in adults primarily affects the muscles of the face, shoulders, and upper arms. It is generally characterized by progressive weakness and wasting of these muscles. It leads to difficulties with facial expressions, shoulder movement, and arm strength. FSHD can present in adulthood, typically in the second or third decade of life, although onset may occur at any age. The severity of signs can vary widely among affected individuals, even within the same family. Common symptoms include asymmetrical weakness of facial muscles and difficulty raising the arms. Also, individuals may experience scapular winging. 

Bethlem Myopathy

This is one of the rare muscle disorders listed. It primarily affects adults. Symptoms can sometimes appear in childhood. It is generally characterized by progressive muscle weakness and joint stiffness. It is mainly in the hands, fingers, and ankles. The hallmark feature of Bethlem myopathy is the involvement of both skeletal and smooth muscles. It is leading to difficulties with mobility and everyday activities. Individuals with those illnesses may experience contractures. They are permanent shortening of muscles or tendons, limiting joint movement. Mutations in the COL6A1, COL6A2, or COL6A3 genes usually cause the condition. They encode collagen VI proteins necessary for maintaining muscle structure and function.

Neuromuscular Diseases List


Neuromuscular illnesses encompass a diverse group of conditions. They affect the nerves controlling voluntary muscles. It leads to weakness, paralysis, and other signs. These disorders can arise from genetic mutations, autoimmune reactions, infections, or environmental factors. Common examples include muscular dystrophy, amyotrophic lateral sclerosis (ALS), and myasthenia gravis. Understanding the complexities of these conditions is crucial. It helps for accurate diagnosis and effective management. We’ll explore the characteristics and treatments of various neuromuscular diseases listed. They’ll help provide insight and support for those affected.

Charcot-Marie-Tooth Disease (CMT)

CMT is a group of inherited neurological disorders that affect the peripheral nerves. They lead to muscle weakness and wasting, particularly in the feet, lower legs, hands, and forearms. CMT’s name appears after the three doctors identifying it: Jean-Martin Charcot, Pierre Marie, and Howard Henry Tooth. It is one of the most common inherited neurological disorders. This illness has various subtypes characterized by different genetic mutations. Signs typically manifest during adolescence or early adulthood and progressively worsen over time. Common symptoms include muscle weakness and foot deformities. Among them are high arches or hammertoes, difficulty walking, and loss of sensation in the extremities.

Guillain-Barré Syndrome (GBS)

This rare muscle disease in adults is usually characterized by the immune system’s attack on the peripheral nerves. This leads to muscle weakness, paralysis, and, in severe cases, respiratory failure. GBS often begins with tingling sensations and weakness in the legs, which then spreads to the arms and upper body. In some cases, it can progress rapidly, causing complete paralysis within a few weeks. The exact cause of GBS is not fully understood, but an infection, such as a respiratory or gastrointestinal illness, often precedes it. The immune system’s response to the infection mistakenly damages the myelin sheath. Also, it harms the protective covering of the nerves, disrupting nerve function.

Friedreich’s Ataxia

Such a condition is a progressive, degenerative neuromuscular disease list. It is usually characterized by muscle weakness, loss of coordination, and impaired speech. The genetic mutation that affects the production of a protein called frataxin causes it. It is essential for the proper function of the mitochondria. The energy-producing structures within cells. This mutation leads to mitochondrial dysfunction and oxidative stress. It is mainly in the spinal cord and peripheral nerve cells. Individuals with Friedreich’s Ataxia typically experience progressive difficulty with walking, coordination, and balance. Other common symptoms include muscle weakness, vision and hearing impairment, and cardiomyopathy. This is a heart muscle weakening.


Understanding the signs and treatments of our muscle disease list is vital for effective management. Also, it helps to improve quality of life. We explore all varieties of this group of diseases. Each disorder presents unique challenges. We aim to enhance patient care at Lone Star Neurology. We offer early detection, personalized treatment plans, and ongoing research. Together, we can continue to support individuals affected by these conditions. Also, we may strive for advancements in neuromuscular health.


What are the most common symptoms of muscle diseases?

The most common symptoms of muscle diseases include muscle weakness, fatigue, and pain. Also, they involve difficulty with mobility.

How are muscle diseases diagnosed?

Muscle diseases are often diagnosed through medical history evaluation and physical examination. Also, imaging tests and specialized muscle function tests are pivotal.

Can muscle diseases be cured?

Some signs of muscle diseases can be generally managed, and the quality of life can be significantly improved with treatment. Most muscle diseases currently do not have a cure.

What lifestyle changes can help manage muscle diseases?

Lifestyle changes include regular exercise, a balanced diet, and managing stress. Also, they involve avoiding overexertion. They can help manage symptoms and improve overall well-being in individuals with muscle diseases.

Are muscle diseases genetic?

Many muscle diseases have a genetic component. Mutations or abnormalities in genes responsible for muscle function usually cause it.


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Edward Medina
Edward Medina
15:34 30 Jun 22
Just such an amazing staff that makes you feel like part of their family. I’ve been going there for over 5 years now... and each visit I get the very best care and treatments that I have ever received in the 20+ years that I’ve been dealing with severe debilitating migraines. Since i started seeing them the number of my migraines has dropped from 15-20 a month to 2-3 every 3 month. I highly recommend them …they will change your life!read more
Daneisha Johnson
Daneisha Johnson
22:20 19 May 22
Dr. Askari was very kind and explained everything so I could understand. The other staff were nice as well. I would... have gave 5 stars but I was a little taken aback when I checked in and had to pay 600.00 upfront. I think that should have been discussed in a appointment confirmation call or email just so I could have been more
Jean Cooper
Jean Cooper
16:54 29 Apr 22
I love the office staff they are friendly and very helpful. Dr. JODIE is very caring and understanding to your needs... and wants to help you. I will go back. would recommend Dr. Dr. Jodie to other Patients in a heart beat. The team works well more
Linda M
Linda M
19:40 02 Apr 22
I was obviously stressed, needing to see a neurologist. The staff was so patient and Dr. Ansari was so kind. At one... point he told me to relax, we have time, when I was relaying my history of my condition. That helped ease my stress. I have seen 3 other neurologists and he was the only one who performed any assessment tests on my cognitive and physical skills. At one point I couldn't complete two assessments and got upset and cried. I was told, it's OK. That's why you're here. I was truly impressed, and super pleased with the whole experience!read more
Leslie Durham
Leslie Durham
15:05 01 Apr 22
I've been coming here for about 5 years. The staff are ALWAYS friendly and knowledgeable. The Doctors are the absolute... best!! Jodie Moore is always in such a great mood which is a plus when you are already stressed. Highly recommendedread more
Monica Del Bosque
Monica Del Bosque
14:13 25 Mar 22
Since my first post my thoughts have changed here. It's unfortunate. My doctor and PA were great, but the office staff... is horrible. They never call you back when they say they will, they misinform you, they cause you too much stress wondering what's going on, they don't keep you posted. They never answer the phone. At this point I've left four messages in the last week, and I have sent three messages. Twice from their portal and one direct email. No response. My appointment is on Monday morning at 8:30am, no confirmation on my insurance and what's going on. What the heck is going on, this is ridiculous!I've given up... the stress her office staff has put me through is just not worth it. You can do so much better, please clean house, either change out your office staff, or find a way for them to be more efficient please. You have to do something. This is not how you want to run your practice. It leaves a very bad impression on your more
Ron Buckholz
Ron Buckholz
23:32 23 Mar 22
I was actually pleasantly surprised with this visit! It took me a long time to get the appointment scheduled because no... one answers your phones EVER! After a month, I finally got in, and your staff was warm, friendly, and I was totally impressed! I feel like you will take care of my needs!read more
Steve Nabavi
Steve Nabavi
16:28 16 Mar 22
It was a nice visit. Happy staff doing all they can do to comfort the patients in a very calming environment. You ask... me they are earned a big gold star on the fridge. My only complaint they didn't give me any more
Katie Lewis
Katie Lewis
16:10 10 Feb 22
Had very positive appointments with Jodie and Dr. Sheth for my migraine care. Jodie was so fast with the injections and... has so much valuable info. I started to feel light headed during checkout and the staff was SO helpful—giving me a chair, water, and taking me into a private room until I felt better. Highly recommend this practice for migraine patients, they know what they’re doing!!read more
Joshua Martinez
Joshua Martinez
16:02 10 Dec 21
I was scheduled to be checked and just want to say that the staff was fantastic. They were kind and helpful. I was... asked many questions related to what was going on and not once did I feel as though I was being brushed off. The front desk staff was especially great in assisting me. I'm scheduled to go back for a mri and am glad that I'll be going more
Isabel Ivy
Isabel Ivy
21:42 03 Nov 21
I had such a good experience with Lone Star Neurology, Brent my MRI Tech was so awesome and made sure I was very... comfortable during the appointment. He gave me ear plugs, a pillow, leg support and blanket, easiest MRI ever lol 🤣 My 72 hour EEG nurse Amanda was also so awesome. She made sure I was take care of over the 3 days and took her time with the electrodes to make sure it was comfortable for me! Paige was also a huge help in answering all my questions when it came to my test results, and letting me know her honest opinions about how I should go forth with my more
Leslie Luce
Leslie Luce
17:37 20 Oct 21
The professionalism and want to help attitude of this office was present from the moment I contacted them. The follow... up and follow through as well as their willingness to find a way to schedule my dad was above and beyond. We visited two offices in the same day with the same experience. I am appreciative of this—we spend a lot of time with doctors and this was top notch start to more
robert Parker
robert Parker
16:38 16 Apr 21
I love going to this office. The staff is friendly and helpful. The doctor is great. I am getting the best... neurological tests and treatment I have ever had. The only reason I did not give them a 5 star rating is because it is impossible to reach a live person at the office to reschedule appointments. Every time I have tried to get through to the office it says all people are busy and I am sent to a voicemail. If they could get their phone answering fixed, I would give them a strong 5 more
MaryAnn Hornbaker
MaryAnn Hornbaker
00:26 25 Feb 21
Dr. Harney is an excellent Dr. I found him friendly , personable and thorough. I evidently am an unusual case. ... Therefore he spent a Hugh amount of time educating me. He even gave me literature to further explain my condition and how to follow up. This is something you rarely get from your doctors. So I am more than please with my doctor and his more
Roger Arguello
Roger Arguello
03:05 29 Jan 21
Always courteous, professional. The staff is very friendly and always work with you to find the best appointment time.... The care team has been great. Always taking the time to listen to your concerns and to find the best more
Margaret Rowland
Margaret Rowland
01:12 27 Jan 21
I have been a patient at Lone Star Neurology for several years. Now both my adult daughters also are patients there. I... love Jodie. She is always so prompt whether it is a teleamed call are a visit in the office. She takes the time to explain everything to me and answers all my questions. I am so blessed to have Jodie as my more
Susan Miller
Susan Miller
03:01 13 Jan 21
My husband had an accident 5 years ago and Lone Star Neurology has been such a blessing to us with my husbands care.... Jodie Moore is his provider and she is amazing! Jodie is very knowledgeable, caring, and thorough. She takes her time with you, making sure your needs are met and she is happy to answer any questions you may have. Lone Star Neurology’s patients are very lucky to have Jodie providing their care. Thank you Lone Star Neurology and especially Jodie for everything you have done for us. Jodie, you are the best!read more
Windalyn C
Windalyn C
01:32 09 Jan 21
Jodie is wonderful. She is very caring and knowledgeable. I have been to over a dozen neurologists, and none were able... to help me as much as they have here. Thanks!read more
Katie Kordel
Katie Kordel
00:40 09 Jan 21
Jodi Moore, nurse practitioner, is amazing. I have suffered from frequent, debilitating headaches for almost 20 years.... She has provided the best proactive and responsive care I have ever received. My quality of life has been greatly improved by her caring approach and tenacity in finding more
Ellie Natsis
Ellie Natsis
15:41 07 Jan 21
I have had the best experience at this neurologist's office! For over a year I have been receiving iv treatments here... each month and my nurse, Bobbie is beyond wonderful!! She's so attentive, knowledgeable, caring, and detail oriented. She makes an otherwise uncomfortable experience much more pleasant and definitely puts me at ease! She also helps me with my insurance,ordering this specialty medication and dealing with the ordering process which is no easy feat.Needless to say, she goes above a beyond in every way and I'm so grateful to this office and to Bobbie for all they do for me!read more
Matt Morris
Matt Morris
15:39 07 Jan 21
Let me start by saying that I have been coming here for years. Due to my autoimmune disease, I am in this office... once every three weeks for multiple hours at a time. The office is very clean and the staff very friendly. My only complaint would be there communication via phone. They aren't the best at responding if you leave a voicemail and expect a call back. I understand that this is prob just due to the sheer number of alls they receive daily. What I can say I like the best about the office are the people. Bobby who handles my infusions is great. I never have any issues with her setting up my infusions. She is very quick to reply to messages sent via text and if she were to leave then my whole opinion of the office may change. I also enjoy people like Matt, Lauren, and Jodi. I appreciate all that they do for me and without this team I'm not sure I would be as happy as I am to visit the office as frequently as I have to. Please ensure that these folks are recognized as they are what makes my visit to this office so tolerable :).read more
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