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COVID-19 and Neurological Damage: Insights & Considerations

Sandeep Dhanyamraju MD
Medically reviewed by Sandeep Dhanyamraju
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Sandeep Dhanyamraju MD
Medically reviewed by Sandeep Dhanyamraju

The COVID-19 pandemic is unfolding like a mysterious saga in the health sector. Each time, it reveals new chapters of its impact. A little-known fabula has emerged amid this chaos – the link between COVID-19 and neurological damage

As the virus continues its global tour, medical experts have turned their eyes to understanding its intricate dance with the brain. From perplexing cases of sudden strokes to lingering symptoms of brain fog. The virus seems to leave no stone unturned on the nervous system. 

In this study, we dive into the depths of COVID neurological damage. We are looking for insights and considerations that may light the way to better understanding and treating the effects of COVID-19. Get ready for a journey through the tangled web of neurons. Here, each discovery brings us closer to unraveling the mysteries of this unprecedented health crisis.

The Link Between COVID-19 and Neurological Damage

The link between COVID and neurological damage has become evident as research progresses. Here are several key points highlighting the expected effects of this virus:

  • Direct Viral Invasion: Coronavirus can directly invade the central nervous system. It leads to neurological complications. This invasion may occur through the bloodstream or the olfactory nerve. It causes inflammation and damage to brain cells.
  • Cytokine Storm: The immune response triggered by COVID-19, known as a cytokine storm, can lead to inflammation in the brain. This excessive inflammation can result in neurological signs. Among them are confusion, delirium, and even encephalitis.
  • Blood Clotting: Coronavirus has been generally associated with an increased risk of blood clot formation. It can lead to strokes and other cerebrovascular events. These clotting issues can cause significant neurological damage and long-term complications.
  • Long COVID: Some individuals experience lingering signs long after the initial infection resolves. Neurological symptoms include brain fog, memory problems, and fatigue. They are commonly reported in patients with long-term COVID-19, indicating persistent neurological effects.
  • Impact on Mental Health: Stress, isolation, and uncertainty are dangerous. They have contributed to increased rates of anxiety, depression, and other conditions. Such consequences further highlight the neurological effects of COVID.
  • Neurological Manifestations in Children: Coronavirus generally causes milder signs in children. There have been reports of neurological manifestations. Among them are headaches, seizures, and altered mental status in pediatric patients.
  • Neurological Damage in Severe Cases: Patients with severe COVID-19 often experience multi-organ failure. It includes several neurological complications. Among them is hypoxic brain injury due to respiratory failure, which can result in long-term cognitive impairment.

Understanding the complex interplay between COVID and neurological damage is crucial. It helps to manage and treat patients affected by the virus effectively. Ongoing research is essential to elucidate the mechanisms underlying these neurological effects. Also, it develops strategies to mitigate their impact.

Post-COVID Neurological Symptoms
COVID Symptoms

After recovery from a virus illness, symptoms often persist. They refer to post-COVID neurological symptoms can be both perplexing and distressing. The virus primarily affects the respiratory system. Growing evidence suggests that it can also profoundly affect the nervous ones. It is from cognitive difficulties to persistent headaches and fatigue. Understanding and addressing these post-virus neurological signs is essential. It helps for comprehensive patient care and recovery.

Cognitive Impairment

This deterioration refers to deficits in cognitive function. People usually experience it after recovery. Such impairment can manifest as problems with memory, concentration, attention, and executive functions. It may persist for weeks to months after the acute phase of the illness has resolved. Cognitive impairment affects daily functioning and quality of life for some individuals. Common signs reported by coronavirus survivors include brain fog and difficulty multitasking. Also, they involve mental slowness and forgetfulness. The exact mechanisms underlying these post-COVID neurological symptoms are still under investigation. But, they may include a combination of factors. Among them are neuroinflammation, hypoxia-related brain damage, and psychological distress. Management strategies may consist of cognitive rehabilitation, pharmacotherapy, and lifestyle modifications. They help to support cognitive function and recovery.

Fatigue and Weakness

They are common post-illness neurological signs experienced by many individuals. This lingering fatigue can persist for weeks or even months after the acute phase of the illness has resolved. Weakness may accompany fatigue. It is leading to decreased energy levels and diminished physical stamina. These manifestations can significantly impact daily functioning and quality of life. They require adequate rest and gradual rehabilitation to overcome. Healthcare workers must address fatigue and weakness following the coronavirus. It is also essential to manage them with individual treatment plans tailored to the needs of each patient.

Headaches and Migraines

Experiencing these signs is a prevalent concern among individuals with post-COVID neurological symptoms. These headaches can vary in intensity and duration. Other neurological issues often accompany them. The exact mechanisms behind these symptoms are unsteadiness. They can significantly impact the quality of life for those affected. Managing post-coronavirus headaches and migraines may require a multidisciplinary approach. It includes medication, lifestyle modifications, and other therapeutic interventions. Treatment aims to alleviate discomfort and improve overall well-being.

Long-term Neurological Effects of COVID-19

The durable effects of this virus can persist beyond the acute phase of the illness. They affect individuals months after recovery. Common symptoms include cognitive impairment. Among them are brain fog and memory problems, along with persistent fatigue and weakness. Headaches and migraines may also become chronic. Understanding and addressing these long-term neurological effects of COVID-19 are essential. They help to provide comprehensive care to individuals recovering from the virus.

Memory Loss and Cognitive Decline

Some individuals who have recovered from the virus experience these signs. They suffer from difficulties with memory, concentration, and mental clarity. This cognitive impairment can range from mild to severe and may persist for an extended period after the acute phase of the illness has passed. Research suggests that COVID-19-related cognitive decline may result from various factors. They are direct viral invasion of the central nervous system, inflammation, and vascular damage. Management strategies may involve cognitive rehabilitation and lifestyle modifications. Also among them is ongoing medical monitoring to address these persistent neurological signs.

Chronic Fatigue Syndrome (CFS)

CFS is a debilitating condition characterized by persistent fatigue. It is among the long-term neurological effects of COVID-19. Emerging evidence suggests that survivors may experience prolonged fatigue. It may be even after recovery from the acute phase of the illness. This fatigue can significantly impact daily functioning and quality of life. The exact mechanisms underlying CFS in SARS-CoV-2 are still being directly investigated. It underscores the importance of support for individuals experiencing long-term neurological symptoms post-infection. Early intervention and management strategies are essential. They help to address CFS’s complex challenges in coronavirus survivors.

Neuropathic Pain

This is a significant concern in the long COVID neurological disease. It manifests as chronic, shooting, or burning sensations, often occurring in the limbs. This pain arises from damage or dysfunction in the nervous system, leading to abnormal signaling. Neuropathic pain can persist for months after the acute infection subsides in coronavirus patients. It significantly impacts the quality of life. Management typically involves a multidisciplinary approach, including medications, physical therapy, and psychological support. Understanding and addressing neuropathic pain are crucial aspects. They help to care for individuals experiencing long-term neurological complications following SARS-CoV-2 infection.

Why are Neurological Diseases Progressing with COVID-19?People Neurological Dise COVID-19

There are several factors contributing to the persistence of neurological symptoms after COVID-19. Among them are:

  • Inflammatory Response: Coronavirus triggers an inflammatory response. It can lead to inflammation in the brain, exacerbating existing neurological conditions.
  • Direct Viral Invasion: The virus can directly invade the central nervous system. It causes neurological damage and long-term complications.
  • Blood Clotting: Coronavirus increases the risk of blood clot formation. It leads to strokes and other cerebrovascular events, exacerbating neurological symptoms.
  • Persistent Infection: Some patients experience long COVID neurological disease. There, neurological symptoms persist long after the initial infection resolves. Such a disease indicates ongoing neurological damage.
  • Neurological Manifestations of Post-Viral Syndrome: Long coronavirus shares similarities with post-viral syndromes. Viral infections can trigger these signs due to immune dysregulation and neuroinflammation.
  • Underlying Health Conditions: COVID survivors may be more susceptible to developing long-term effects. Among such patients are those with pre-existing neurological conditions or risk factors.

Continued research into the neurological symptoms after COVID-19 is critical. It helps address the needs of individuals affected by the virus. The latest research significantly improves their quality of life.

Do People with Chronic Neurological Diseases Take COVID-19 Harder?

People with these diseases may experience more severe signs if they contract COVID-19 due to various factors. Here’s why long COVID neurological disease may affect them harder:

  • Weakened Immune System: Chronic neurological illnesses can weaken the immune system. They make individuals more susceptible to infections like coronavirus. Also, such illnesses potentially increase the severity of the disease.
  • Underlying Health Conditions: Individuals with chronic neurological diseases often have other comorbidities. Among them are cardiovascular disease or respiratory issues. They can exacerbate COVID-19 symptoms and lead to complications.
  • Respiratory Complications: Certain neurological conditions may affect respiratory function. They make it harder for individuals to recover from these signs associated with SARS-CoV-2. Among them are pneumonia or acute respiratory distress syndrome (ARDS).
  • Medication Interactions: Some using drugs may interact with coronavirus treatments. They complicate the management of both conditions.
  • Increased Risk of Long-Term Effects: Individuals with such diseases are at a higher risk. They may experience long-term neurological effects of COVID-19. Among them is cognitive decline or neuropathic pain due to the underlying vulnerability of their nervous system.

Individuals with chronic neurological diseases must take extra precautions. They help minimize their risk of contracting coronavirus and monitor their health if infected.

Managing and Mitigating Neurological Symptoms After COVID-19 

Managing COVID neurological damage requires a multifaceted approach prioritizing physical and mental well-being. This includes close monitoring of symptoms and implementing targeted therapies. Also, it involves providing comprehensive support to individuals affected by post-coronavirus neurological signs. Fostering collaboration between healthcare professionals, researchers, and patients is crucial. So we can better understand the underlying mechanisms of neurological damage. Also, we may develop tailored interventions to improve results and enhance the quality of life for those impacted by coronavirus.


Can COVID-19 cause permanent neurological damage?

Yes, COVID-19 can cause permanent neurological damage. It is particularly in severe cases or individuals with underlying health conditions.

What are the most common neurological symptoms after COVID?

The most common neurological symptoms after COVID-19 include fatigue, headaches, brain fog, and loss of smell or taste.

How can I protect myself from the neurological effects of COVID?

To protect yourself from the neurological effects, follow recommended public health guidelines. Wear masks, practice hand hygiene, maintain physical distance, and get vaccinated when eligible.

Is there a link between COVID-19 and the development of neurological diseases?

Yes, there is evidence suggesting a link between COVID-19 and the development of neurological diseases. It includes acute conditions. Among them are encephalitis and strokes, as well as long-term neurological signs associated with the long-term virus.

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Edward Medina
Edward Medina
15:34 30 Jun 22
Just such an amazing staff that makes you feel like part of their family. I’ve been going there for over 5 years now... and each visit I get the very best care and treatments that I have ever received in the 20+ years that I’ve been dealing with severe debilitating migraines. Since i started seeing them the number of my migraines has dropped from 15-20 a month to 2-3 every 3 month. I highly recommend them …they will change your life!read more
Daneisha Johnson
Daneisha Johnson
22:20 19 May 22
Dr. Askari was very kind and explained everything so I could understand. The other staff were nice as well. I would... have gave 5 stars but I was a little taken aback when I checked in and had to pay 600.00 upfront. I think that should have been discussed in a appointment confirmation call or email just so I could have been more
Jean Cooper
Jean Cooper
16:54 29 Apr 22
I love the office staff they are friendly and very helpful. Dr. JODIE is very caring and understanding to your needs... and wants to help you. I will go back. would recommend Dr. Dr. Jodie to other Patients in a heart beat. The team works well more
Linda M
Linda M
19:40 02 Apr 22
I was obviously stressed, needing to see a neurologist. The staff was so patient and Dr. Ansari was so kind. At one... point he told me to relax, we have time, when I was relaying my history of my condition. That helped ease my stress. I have seen 3 other neurologists and he was the only one who performed any assessment tests on my cognitive and physical skills. At one point I couldn't complete two assessments and got upset and cried. I was told, it's OK. That's why you're here. I was truly impressed, and super pleased with the whole experience!read more
Leslie Durham
Leslie Durham
15:05 01 Apr 22
I've been coming here for about 5 years. The staff are ALWAYS friendly and knowledgeable. The Doctors are the absolute... best!! Jodie Moore is always in such a great mood which is a plus when you are already stressed. Highly recommendedread more
Monica Del Bosque
Monica Del Bosque
14:13 25 Mar 22
Since my first post my thoughts have changed here. It's unfortunate. My doctor and PA were great, but the office staff... is horrible. They never call you back when they say they will, they misinform you, they cause you too much stress wondering what's going on, they don't keep you posted. They never answer the phone. At this point I've left four messages in the last week, and I have sent three messages. Twice from their portal and one direct email. No response. My appointment is on Monday morning at 8:30am, no confirmation on my insurance and what's going on. What the heck is going on, this is ridiculous!I've given up... the stress her office staff has put me through is just not worth it. You can do so much better, please clean house, either change out your office staff, or find a way for them to be more efficient please. You have to do something. This is not how you want to run your practice. It leaves a very bad impression on your more
Ron Buckholz
Ron Buckholz
23:32 23 Mar 22
I was actually pleasantly surprised with this visit! It took me a long time to get the appointment scheduled because no... one answers your phones EVER! After a month, I finally got in, and your staff was warm, friendly, and I was totally impressed! I feel like you will take care of my needs!read more
Steve Nabavi
Steve Nabavi
16:28 16 Mar 22
It was a nice visit. Happy staff doing all they can do to comfort the patients in a very calming environment. You ask... me they are earned a big gold star on the fridge. My only complaint they didn't give me any more
Katie Lewis
Katie Lewis
16:10 10 Feb 22
Had very positive appointments with Jodie and Dr. Sheth for my migraine care. Jodie was so fast with the injections and... has so much valuable info. I started to feel light headed during checkout and the staff was SO helpful—giving me a chair, water, and taking me into a private room until I felt better. Highly recommend this practice for migraine patients, they know what they’re doing!!read more
Joshua Martinez
Joshua Martinez
16:02 10 Dec 21
I was scheduled to be checked and just want to say that the staff was fantastic. They were kind and helpful. I was... asked many questions related to what was going on and not once did I feel as though I was being brushed off. The front desk staff was especially great in assisting me. I'm scheduled to go back for a mri and am glad that I'll be going more
Isabel Ivy
Isabel Ivy
21:42 03 Nov 21
I had such a good experience with Lone Star Neurology, Brent my MRI Tech was so awesome and made sure I was very... comfortable during the appointment. He gave me ear plugs, a pillow, leg support and blanket, easiest MRI ever lol 🤣 My 72 hour EEG nurse Amanda was also so awesome. She made sure I was take care of over the 3 days and took her time with the electrodes to make sure it was comfortable for me! Paige was also a huge help in answering all my questions when it came to my test results, and letting me know her honest opinions about how I should go forth with my more
Leslie Luce
Leslie Luce
17:37 20 Oct 21
The professionalism and want to help attitude of this office was present from the moment I contacted them. The follow... up and follow through as well as their willingness to find a way to schedule my dad was above and beyond. We visited two offices in the same day with the same experience. I am appreciative of this—we spend a lot of time with doctors and this was top notch start to more
robert Parker
robert Parker
16:38 16 Apr 21
I love going to this office. The staff is friendly and helpful. The doctor is great. I am getting the best... neurological tests and treatment I have ever had. The only reason I did not give them a 5 star rating is because it is impossible to reach a live person at the office to reschedule appointments. Every time I have tried to get through to the office it says all people are busy and I am sent to a voicemail. If they could get their phone answering fixed, I would give them a strong 5 more
MaryAnn Hornbaker
MaryAnn Hornbaker
00:26 25 Feb 21
Dr. Harney is an excellent Dr. I found him friendly , personable and thorough. I evidently am an unusual case. ... Therefore he spent a Hugh amount of time educating me. He even gave me literature to further explain my condition and how to follow up. This is something you rarely get from your doctors. So I am more than please with my doctor and his more
Roger Arguello
Roger Arguello
03:05 29 Jan 21
Always courteous, professional. The staff is very friendly and always work with you to find the best appointment time.... The care team has been great. Always taking the time to listen to your concerns and to find the best more
Margaret Rowland
Margaret Rowland
01:12 27 Jan 21
I have been a patient at Lone Star Neurology for several years. Now both my adult daughters also are patients there. I... love Jodie. She is always so prompt whether it is a teleamed call are a visit in the office. She takes the time to explain everything to me and answers all my questions. I am so blessed to have Jodie as my more
Susan Miller
Susan Miller
03:01 13 Jan 21
My husband had an accident 5 years ago and Lone Star Neurology has been such a blessing to us with my husbands care.... Jodie Moore is his provider and she is amazing! Jodie is very knowledgeable, caring, and thorough. She takes her time with you, making sure your needs are met and she is happy to answer any questions you may have. Lone Star Neurology’s patients are very lucky to have Jodie providing their care. Thank you Lone Star Neurology and especially Jodie for everything you have done for us. Jodie, you are the best!read more
Windalyn C
Windalyn C
01:32 09 Jan 21
Jodie is wonderful. She is very caring and knowledgeable. I have been to over a dozen neurologists, and none were able... to help me as much as they have here. Thanks!read more
Katie Kordel
Katie Kordel
00:40 09 Jan 21
Jodi Moore, nurse practitioner, is amazing. I have suffered from frequent, debilitating headaches for almost 20 years.... She has provided the best proactive and responsive care I have ever received. My quality of life has been greatly improved by her caring approach and tenacity in finding more
Ellie Natsis
Ellie Natsis
15:41 07 Jan 21
I have had the best experience at this neurologist's office! For over a year I have been receiving iv treatments here... each month and my nurse, Bobbie is beyond wonderful!! She's so attentive, knowledgeable, caring, and detail oriented. She makes an otherwise uncomfortable experience much more pleasant and definitely puts me at ease! She also helps me with my insurance,ordering this specialty medication and dealing with the ordering process which is no easy feat.Needless to say, she goes above a beyond in every way and I'm so grateful to this office and to Bobbie for all they do for me!read more
Matt Morris
Matt Morris
15:39 07 Jan 21
Let me start by saying that I have been coming here for years. Due to my autoimmune disease, I am in this office... once every three weeks for multiple hours at a time. The office is very clean and the staff very friendly. My only complaint would be there communication via phone. They aren't the best at responding if you leave a voicemail and expect a call back. I understand that this is prob just due to the sheer number of alls they receive daily. What I can say I like the best about the office are the people. Bobby who handles my infusions is great. I never have any issues with her setting up my infusions. She is very quick to reply to messages sent via text and if she were to leave then my whole opinion of the office may change. I also enjoy people like Matt, Lauren, and Jodi. I appreciate all that they do for me and without this team I'm not sure I would be as happy as I am to visit the office as frequently as I have to. Please ensure that these folks are recognized as they are what makes my visit to this office so tolerable :).read more
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