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All about Medications for Diabetic Neuropathy

Sandeep Dhanyamraju MD
Medically reviewed by Sandeep Dhanyamraju
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Sandeep Dhanyamraju MD
Medically reviewed by Sandeep Dhanyamraju

Diabetic neuropathy is a consequence of metabolic disorders in peripheral nerves. It leads to a change in their structure and functions. The main drugs for this are alpha-lipoic acid drugs and drugs that cut pain syndrome. Besides them, doctors can prescribe the following popular options for diabetic neuropathy medications:

  • Pain relievers;
  • Antidepressants;
  • Opioids;
  • Anticonvulsants.

Medications for diabetic neuropathy work in different ways. They can relieve pain, improve nerve function, and reduce inflammation. For somebody, diabetic neuropathy medicine can work, but for others – it can not. After all, everyone has a different degree of illness and the body’s acceptance of drugs. So, a consultation with a neurologist is essential to determine the correct medication. Besides drugs, specialists sometimes prescribe other types of treatment for diabetic neuropathy. It includes physical therapy, occupational therapy, and lifestyle changes. However, doctors select it for each person individually. They recognize signs and, based on them, choose proper treatment.

 Diabetic Neuropathy Diagnosis

Diagnosing diabetic neuropathy involves a combination of a physical exam and various tests. This disease can affect the nerves throughout the body. But most commonly, it affects the feet and legs. So, diabetic neuropathy diagnosis consists of the following steps:

  • Collection of the patient’s history and complaints

To begin with, the neurologist asks the patient some questions. They ask about the symptoms, the onset of the disease, and other conditions. Collecting general information helps to find the cause of the illness faster.

  • Electromyography

This test measures the electrical activity in muscles. It can help determine if there is muscle and nerve damage.

  • Electrocardiography

It is the definition of heart rate variability. For this, doctors conduct a test with deep breathing, a Valsalva test, and a test with a change in body position.

  • Neurological examination

This step of diabetic neuropathy diagnosis involves testing nerve function. It includes reflexes, sensation, and muscle strength.

  • Skin biopsy

Specialists take a small skin sample from the affected area. And then, they examine it under a microscope to look for nerve damage.

It tests the speed of electrical impulses in the nerves. It can help determine if there is nerve damage and its severity.

  • Autonomic testing

It means testing the function of the autonomic nerves. Those control involuntary functions such as blood pressure and heart rate.

If you have diabetes and are experiencing symptoms such as tingling, numbness, or pain in your feet or hands, talk to your neurologist. They will prescribe diabetic nerve pain medication. Thus, a timely visit can help protect you from the terrible consequences of this illness.

neuropathy diabetes treatment

Treatment for Diabetic Neuropathy

Effective neuropathy diabetes treatment is impossible without achieving diabetes compensation. Specialists carry out the treatment of diabetic neuropathy in stages. First of all, they prescribe antidiabetic tablets or insulin to the patient. And they also measure the level of glucose in the body. During the treatment of this illness, doctors additionally recommend to the patient such diabetic neuropathy medications:

  • optimal diet;
  • load mode;
  • reduction of excess weight;
  • maintaining an average blood pressure level.

The main course of diabetic neuropathy medicine also includes taking vitamins and antioxidants. They strengthen immunity and slow down symptoms. In case of pain, doctors prescribe the patient anticonvulsants and analgesics. But for the treatment to be faster and more effective, there are other ways to do it:

1. Blood sugar control

Keep your blood sugar levels under control. It is one of the most important ways of neuropathy diabetes treatment. It can help slow down the disease’s progression and prevent further nerve damage:

  • By controlling blood sugar levels through diet, exercise, and medication as needed, you can reduce the amount of excess sugar in the bloodstream. 
  • It helps prevent further damage to the nerves. 
  • Besides, it may even allow damaged nerves to heal to some extent.
  • Controlling blood sugar levels can also help improve circulation. It can further reduce the risk of nerve damage.

2. Medications

There are popular diabetic neuropathy medications that you can use to treat this disease:

  • Pain relievers. Over-the-counter pain relievers include acetaminophen, ibuprofen, and aspirin. You can use them to treat mild to moderate pain due to diabetic neuropathy.
  • Topical creams. You can apply topical creams containing capsaicin or lidocaine to the affected area. It provides temporary relief from pain.
  • Anticonvulsants. They are effective in treating nerve pain associated with diabetic neuropathy. You can also use medications to treat seizures, such as gabapentin and pregabalin. 
  • Antidepressants. Doctors can prescribe you antidepressants such as amitriptyline, duloxetine, and venlafaxine. These diabetic neuropathy medications work by altering the levels of certain chemicals in the brain.

3. Physical therapy

This option can be helpful for people with diabetic neuropathy. Because it can improve strength and flexibility, reduce pain, and improve balance. These neuropathy diabetes treatments can help reduce the risk of falls and injuries. All these can be a significant concern for people with diabetic neuropathy. So, doing physical therapy is essential for both emotional and physical health:

  • Sometimes, physical therapists can create a customized exercise program. 
  • This program may include exercises to improve strength in the muscles of the feet, legs, and hands. 
  • Besides, it involves activities to improve flexibility and range of motion. 
  • It is tailored to the individual’s needs and abilities.

4. Transcutaneous electrical nerve stimulation (TENS)

The next diabetic nerve pain medication is TENS therapy. It involves using a small device:

  • It sends electrical impulses to the nerves. 
  • TENS treats a variety of conditions, including diabetic neuropathy. 
  • It can help relieve pain and improve circulation. 
  • It’s because the electrical impulses delivered by the TENS device cause the blood vessels to dilate. 
  • This way, it increases blood flow and oxygen supply to the nerves. 

TENS can be used alone or in combination with other neuropathy diabetes treatments. Among options can be medication or physical therapy. But it is important to note that for some, such treatment of diabetic neuropathy can be helpful. And for others, it’s, on the contrary, not effective. After all, everyone perceives such a procedure differently. Therefore, you should discuss diabetic neuropathy medicine with a doctor.

5. Surgery

When no type of diabetic nerve pain medication helps, people need surgery. It can relieve pressure on the nerves and reduce pain. There are various surgical procedures that doctors do to treat diabetic neuropathy:

It involves implanting a device that delivers electrical impulses to the spinal cord.

  • Nerve decompression surgery

This type of surgery treats peripheral neuropathy. The procedure involves releasing pressure on the affected nerves. This way, it removes surrounding tissue or bone.

  • Joint replacement surgery

For some people with diabetic neuropathy, joint damage can cause mobility issues. Joint replacement surgery can relieve pain and improve mobility.

  • Amputation

In severe cases of diabetic neuropathy, amputation may be necessary to remove a limb that has become severely infected or has not healed correctly. But amputation is generally a last resort in diabetic neuropathy medicine.

What Is the Best Medication to Take for Neuropathy?

The best diabetic neuropathy medications depend on the individual case. Besides, it can vary based on factors such as the severity of symptoms, the type of neuropathy, and other underlying health conditions. Some medications that are commonly used to manage diabetic neuropathy signs include:

Which is the best of them? Only a neurologist can give you the answer. Based on your symptoms and the stage of the disease, they know which diabetic nerve pain medication will work best for you. Working with a doctor to determine the most appropriate treatment plan is essential. Proper management of diabetes and related health conditions, such as high blood pressure, can also help prevent or slow the progression of diabetic neuropathy.

Determining the best neuropathy diabetes treatment requires a comprehensive evaluation by a specialist. Consider your medical history and other medications. Your doctor will also consider your medical history when determining your best prescription. Certain diabetic nerve pain medications may interact with others you are taking or exacerbate other health conditions. Thus, only this approach to treatment can give you an understanding of which drugs are best for you.

A Word From Lone Star Neurologists

Diabetic neuropathy is a condition that can cause significant discomfort in life. And unfortunately, there are no diabetic neuropathy medications that could cure this disease forever. So, the only option to slow down the progress of the disease is to visit a neurologist. And Lone Star Neurologists can be an excellent option for you. We will help you cope with any neurological conditions of any complexity. Thanks to our medical innovations, we will keep your health in balance. 


  • Which drug is best for diabetic neuropathy?

The best drug for diabetic neuropathy is the one prescribed by your doctor. After all, each body takes the same medicine differently. Accordingly, treatment can be different for everyone. But the most popular drug for diabetic neuropathy is tricyclic antidepressants.

  • What is the first-line treatment of diabetic neuropathy?

It is the first treatment for a disease that has not yet begun to progress but has only just appeared. It is usually a medicine with no complex composition and a small dose. First-line therapies include tricyclic antidepressants, serotonin–noradrenaline, and anticonvulsants.

  • What vitamins are good for diabetic neuropathy?

It includes all vitamins of group B. They are the most useful in treating neuropathy because they protect the sheath of nerve endings. Among the products with vitamin B are eggs, pork, beans, and nuts.

  • What makes diabetic neuropathy worse?

Bad habits can make diabetic neuropathy progress. It includes smoking, drugs, and a sedentary lifestyle. All of these patterns will worsen neuropathic symptoms and aggravate the stages of the disease.

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Edward Medina
Edward Medina
15:34 30 Jun 22
Just such an amazing staff that makes you feel like part of their family. I’ve been going there for over 5 years now... and each visit I get the very best care and treatments that I have ever received in the 20+ years that I’ve been dealing with severe debilitating migraines. Since i started seeing them the number of my migraines has dropped from 15-20 a month to 2-3 every 3 month. I highly recommend them …they will change your life!read more
Daneisha Johnson
Daneisha Johnson
22:20 19 May 22
Dr. Askari was very kind and explained everything so I could understand. The other staff were nice as well. I would... have gave 5 stars but I was a little taken aback when I checked in and had to pay 600.00 upfront. I think that should have been discussed in a appointment confirmation call or email just so I could have been more
Jean Cooper
Jean Cooper
16:54 29 Apr 22
I love the office staff they are friendly and very helpful. Dr. JODIE is very caring and understanding to your needs... and wants to help you. I will go back. would recommend Dr. Dr. Jodie to other Patients in a heart beat. The team works well more
Linda M
Linda M
19:40 02 Apr 22
I was obviously stressed, needing to see a neurologist. The staff was so patient and Dr. Ansari was so kind. At one... point he told me to relax, we have time, when I was relaying my history of my condition. That helped ease my stress. I have seen 3 other neurologists and he was the only one who performed any assessment tests on my cognitive and physical skills. At one point I couldn't complete two assessments and got upset and cried. I was told, it's OK. That's why you're here. I was truly impressed, and super pleased with the whole experience!read more
Leslie Durham
Leslie Durham
15:05 01 Apr 22
I've been coming here for about 5 years. The staff are ALWAYS friendly and knowledgeable. The Doctors are the absolute... best!! Jodie Moore is always in such a great mood which is a plus when you are already stressed. Highly recommendedread more
Monica Del Bosque
Monica Del Bosque
14:13 25 Mar 22
Since my first post my thoughts have changed here. It's unfortunate. My doctor and PA were great, but the office staff... is horrible. They never call you back when they say they will, they misinform you, they cause you too much stress wondering what's going on, they don't keep you posted. They never answer the phone. At this point I've left four messages in the last week, and I have sent three messages. Twice from their portal and one direct email. No response. My appointment is on Monday morning at 8:30am, no confirmation on my insurance and what's going on. What the heck is going on, this is ridiculous!I've given up... the stress her office staff has put me through is just not worth it. You can do so much better, please clean house, either change out your office staff, or find a way for them to be more efficient please. You have to do something. This is not how you want to run your practice. It leaves a very bad impression on your more
Ron Buckholz
Ron Buckholz
23:32 23 Mar 22
I was actually pleasantly surprised with this visit! It took me a long time to get the appointment scheduled because no... one answers your phones EVER! After a month, I finally got in, and your staff was warm, friendly, and I was totally impressed! I feel like you will take care of my needs!read more
Steve Nabavi
Steve Nabavi
16:28 16 Mar 22
It was a nice visit. Happy staff doing all they can do to comfort the patients in a very calming environment. You ask... me they are earned a big gold star on the fridge. My only complaint they didn't give me any more
Katie Lewis
Katie Lewis
16:10 10 Feb 22
Had very positive appointments with Jodie and Dr. Sheth for my migraine care. Jodie was so fast with the injections and... has so much valuable info. I started to feel light headed during checkout and the staff was SO helpful—giving me a chair, water, and taking me into a private room until I felt better. Highly recommend this practice for migraine patients, they know what they’re doing!!read more
Joshua Martinez
Joshua Martinez
16:02 10 Dec 21
I was scheduled to be checked and just want to say that the staff was fantastic. They were kind and helpful. I was... asked many questions related to what was going on and not once did I feel as though I was being brushed off. The front desk staff was especially great in assisting me. I'm scheduled to go back for a mri and am glad that I'll be going more
Isabel Ivy
Isabel Ivy
21:42 03 Nov 21
I had such a good experience with Lone Star Neurology, Brent my MRI Tech was so awesome and made sure I was very... comfortable during the appointment. He gave me ear plugs, a pillow, leg support and blanket, easiest MRI ever lol 🤣 My 72 hour EEG nurse Amanda was also so awesome. She made sure I was take care of over the 3 days and took her time with the electrodes to make sure it was comfortable for me! Paige was also a huge help in answering all my questions when it came to my test results, and letting me know her honest opinions about how I should go forth with my more
Leslie Luce
Leslie Luce
17:37 20 Oct 21
The professionalism and want to help attitude of this office was present from the moment I contacted them. The follow... up and follow through as well as their willingness to find a way to schedule my dad was above and beyond. We visited two offices in the same day with the same experience. I am appreciative of this—we spend a lot of time with doctors and this was top notch start to more
robert Parker
robert Parker
16:38 16 Apr 21
I love going to this office. The staff is friendly and helpful. The doctor is great. I am getting the best... neurological tests and treatment I have ever had. The only reason I did not give them a 5 star rating is because it is impossible to reach a live person at the office to reschedule appointments. Every time I have tried to get through to the office it says all people are busy and I am sent to a voicemail. If they could get their phone answering fixed, I would give them a strong 5 more
MaryAnn Hornbaker
MaryAnn Hornbaker
00:26 25 Feb 21
Dr. Harney is an excellent Dr. I found him friendly , personable and thorough. I evidently am an unusual case. ... Therefore he spent a Hugh amount of time educating me. He even gave me literature to further explain my condition and how to follow up. This is something you rarely get from your doctors. So I am more than please with my doctor and his more
Roger Arguello
Roger Arguello
03:05 29 Jan 21
Always courteous, professional. The staff is very friendly and always work with you to find the best appointment time.... The care team has been great. Always taking the time to listen to your concerns and to find the best more
Margaret Rowland
Margaret Rowland
01:12 27 Jan 21
I have been a patient at Lone Star Neurology for several years. Now both my adult daughters also are patients there. I... love Jodie. She is always so prompt whether it is a teleamed call are a visit in the office. She takes the time to explain everything to me and answers all my questions. I am so blessed to have Jodie as my more
Susan Miller
Susan Miller
03:01 13 Jan 21
My husband had an accident 5 years ago and Lone Star Neurology has been such a blessing to us with my husbands care.... Jodie Moore is his provider and she is amazing! Jodie is very knowledgeable, caring, and thorough. She takes her time with you, making sure your needs are met and she is happy to answer any questions you may have. Lone Star Neurology’s patients are very lucky to have Jodie providing their care. Thank you Lone Star Neurology and especially Jodie for everything you have done for us. Jodie, you are the best!read more
Windalyn C
Windalyn C
01:32 09 Jan 21
Jodie is wonderful. She is very caring and knowledgeable. I have been to over a dozen neurologists, and none were able... to help me as much as they have here. Thanks!read more
Katie Kordel
Katie Kordel
00:40 09 Jan 21
Jodi Moore, nurse practitioner, is amazing. I have suffered from frequent, debilitating headaches for almost 20 years.... She has provided the best proactive and responsive care I have ever received. My quality of life has been greatly improved by her caring approach and tenacity in finding more
Ellie Natsis
Ellie Natsis
15:41 07 Jan 21
I have had the best experience at this neurologist's office! For over a year I have been receiving iv treatments here... each month and my nurse, Bobbie is beyond wonderful!! She's so attentive, knowledgeable, caring, and detail oriented. She makes an otherwise uncomfortable experience much more pleasant and definitely puts me at ease! She also helps me with my insurance,ordering this specialty medication and dealing with the ordering process which is no easy feat.Needless to say, she goes above a beyond in every way and I'm so grateful to this office and to Bobbie for all they do for me!read more
Matt Morris
Matt Morris
15:39 07 Jan 21
Let me start by saying that I have been coming here for years. Due to my autoimmune disease, I am in this office... once every three weeks for multiple hours at a time. The office is very clean and the staff very friendly. My only complaint would be there communication via phone. They aren't the best at responding if you leave a voicemail and expect a call back. I understand that this is prob just due to the sheer number of alls they receive daily. What I can say I like the best about the office are the people. Bobby who handles my infusions is great. I never have any issues with her setting up my infusions. She is very quick to reply to messages sent via text and if she were to leave then my whole opinion of the office may change. I also enjoy people like Matt, Lauren, and Jodi. I appreciate all that they do for me and without this team I'm not sure I would be as happy as I am to visit the office as frequently as I have to. Please ensure that these folks are recognized as they are what makes my visit to this office so tolerable :).read more
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