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Can Gut Health Influence Neurodegenerative Diseases? Exploring the Science

Sandeep Dhanyamraju
Medically reviewed by Chaitanya Bonda
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Sandeep Dhanyamraju
Medically reviewed by Chaitanya Bonda

The intestine plays a critical role in supporting overall body health. The intestinal tract has a direct connection with the brain. Disruption of its function has a major impact on brain function and health. The gut microbiome contains billions of bacteria that help the body. Research in this area is advancing rapidly and revealing important insights. This connection is called the gut-brain axis, which affects human health. An imbalance in the intestines can disrupt a person’s nervous system function. Maintaining a healthy lifestyle can significantly improve your gut and brain health.

Studies suggest that gut disorders may contribute to the development of Parkinson’s disease or Alzheimer’s disease. Inflammation and gut syndrome are associated with a significant accumulation of plaques in the brain. The brain is responsible for many functions in our body. Disorders in the gut can contribute to neurodegeneration and cause several serious diseases. Early intervention will help determine the cause and prevent the progression of the disease. Doctors will prescribe tests and conduct an examination of the body. A healthy gut is fundamental to overall well being. Intestinal inflammation can contribute to the development of several serious conditions.

The Gut Microbiome and Its Role in Brain Health

Neurologists provide specialized care for people with neurological conditions. Proper medical care can help address these conditions and improve overall health. It’s important to understand that there is a strong connection between the brain and the gut. Intestinal disorders can contribute to several serious health conditions. The gut microbiome includes many trillions of bacteria that live in the digestive tract. They can be found along with viruses and fungi and play a key role in physical and mental health. The gut’s influence on the brain plays a significant role in maintaining good health.

  • A healthy gut microbiome positively affects overall health and helps regulate the immune system. Thanks to its action, the body fights against various infections and inflammation. The microbiome helps fight oxidative stress and protect the brain. As a result, the brain functions normally and is resistant to inflammation. The microbiome protects the brain from premature aging and neurodegeneration. This may help reduce the risk of neurodegenerative diseases.
  • The microbiome produces specific metabolites that affect brain function. Bacteria often synthesize both dopamine and serotonin. These chemicals affect mood, mental activity, and cognitive abilities. The gut microbiome plays a crucial role in regulating brain function. Gut microbes are also involved in the production of fatty acids that have unique properties. They help maintain the barrier and reduce inflammation.

How the Gut-Brain Axis Affects Neurodegeneration

For detailed information about gut-related conditions, it’s important to consult with healthcare professionals. For people with intestinal problems, it is essential to understand what the gut-brain axis is. It is a unique network that connects the central nervous system and the intestinal nervous system. It relies on signals from the immune, hormonal, and neural systems. The gut microbiome has a significant impact on this network. This system can either prevent or contribute to neurodegeneration, depending on its health.

  • When this axis functions properly, inflammation is regulated. A healthy balance is maintained in the body’s metabolic processes. This balanced system supports healthy brain function and immune defense. However, problems with the gut-brain axis cause several serious diseases. Often, a person may have dysbiosis or chronic inflammation of the tract. During long-term exposure, anti-inflammatory cytokines are produced and enter the bloodstream. This inflammatory response leads to neuroinflammation and declining health.
  • Over time, this can lead to serious mental health problems. Studies have shown that disruptions in this balance contribute to the accumulation of harmful substances. The process is often accompanied by cognitive impairment and various diseases. Increased levels of inflammatory proteins can often be detected in the intestines before they appear in the brain. This process warns of inflammation and adverse effects on the brain. Understanding this mechanism helps guide effective treatment approaches. Early intervention when symptoms appear can lead to more effective treatment.

Inflammation’s Role in Gut Health and Neurodegeneration

Persistent inflammation is a significant link between the intestinal tract and various diseases. It is usually related to neurodegenerative diseases and causes serious problems. An intestinal disorder can provoke neuroinflammation and worsen the general condition. Dysbiosis can be a big problem for a person. It increases intestinal permeability and harms the body. Various bacteria and viruses penetrate the systemic bloodstream. The process provokes inflammation of a particular barrier and activates immune cells in the brain. Often, a person may experience a deterioration in cognitive abilities and memory loss. Over time, this may increase the person’s risk of developing diseases such as Alzheimer’s or Parkinson’s. The main mechanisms of inflammation include:

  • Disruption of neural connections.
  • The beginning of the process of neuronal damage.
  • The onset and progression of oxidative stress in the body.
  • Disruption of the blood-brain barrier in the human body.
  • Changes in neurotransmitter metabolism.

Disruption of the intestinal microflora provokes serious diseases. The connection between the brain and the gut is integral. Studies have shown that proper nutrition and a special diet can facilitate this process. To reduce inflammation, it is important for a person to consume healthy foods with micronutrients. Omega-3, amino acids, and B vitamins are essential. A good diet full of vitamins strengthens intestinal barriers. Nutrients and vitamins reach the brain and can improve concentration and memory. Short-chain fatty acids help to exert anti-inflammatory effects. 

The Impact of Dietary Fiber and Probiotics on Gut Health

The-Impact-of-Dietary

Proper nutrition is key to improving gut health. Dietary fiber is one of the best solutions for healthy intestinal metabolism. It has significant neuroprotective potential. Fiber helps the gut produce beneficial short-chain fatty acids. These acids strengthen the intestinal barrier and keep out various bacteria and viruses. They can create a protective barrier that limits the passage of harmful bacteria. Probiotics are another great way to improve overall gut health. They have anti-inflammatory properties and work together with fiber for optimal gut health. A balanced intake of essential fatty acids and vitamins helps improve gut health. Here are the main characteristics of these supplements:

  • Dietary fiber. Fibers found in legumes, fruits, and oats promote the development of beneficial probiotic bacteria. These bacteria improve cognitive function and memory. Resistant starches found in foods like cooled potatoes or green bananas can help enhance beneficial gut bacteria. The insoluble fiber found in grains and nuts is essential for cleansing toxins.
  • Probiotics. Probiotics are beneficial microorganisms found in fermented foods such as yogurt, kefir, sauerkraut, kimchi, and kombucha. They help maintain a healthy gut microbiome by introducing live beneficial bacteria and yeasts. Regular consumption of probiotics can improve digestive health, boost immune function, reduce inflammation, and potentially influence mental health through the gut-brain axis. 

The combination of these products has an additional effect on reducing inflammation. The gut microbiome is very sensitive and needs proper care with vitamins and antioxidants. In the early stages of the disease, these elements will help reduce inflammation.

How Mental Health and Gut Health Are Linked

Mental health is closely related to gut health. The gut is directly connected to the brain through cognitive and emotional centers. This complex system functions optimally when properly cared for. Gut microbes have strong connections to various brain systems. Gut bacteria have a significant impact on human health. These gut bacteria affect the emotional state through several main mechanisms:

  • The effect on mental health is manifested through the production of neurotransmitters. It is known that gut microbes synthesize serotonin with dopamine. Neurotransmitters are central to the regulation of our mood and memory.
  • Neural communication between gut bacteria and the brain is essential. It affects emotional processing and mood regulation.
  • Another mechanism is immune regulation, where the microbiome shapes inflammatory responses.
  • Bacterial metabolites affect brain health and function.

People with anxiety and depression often have gut microbiome disorders. This can lead to inflammation and increase the risk of serious diseases. People with anxiety and depression often show decreased gut microbial diversity. They often have an increased number of anti-inflammatory bacteria. Another demonstration is the change in bacterial metabolites.

Addressing gut health is an essential component of improving mental health. Special medications, diets, and healthy sleep play a key role. Reducing stress can also help improve health. Researchers have observed positive changes in people who maintain healthy dietary habits.

How to Improve Gut Health for Brain Protection

How-to-Improve

There are several ways to improve gut function. The gut plays a vital role in the maintenance and long-term function of the brain. Specific dietary and lifestyle strategies can help create an effective treatment plan. Focusing on diet, lifestyle changes, and the right supplements will help with this. The gut microbiome contains many different beneficial bacteria. Here are a few ways to keep your gut healthy for further brain health:

  • Dietary changes. Increasing dietary fiber intake is a key first step toward better gut health. Add vegetables, fruits, legumes, and whole grains to your diet. Fermented foods will also help introduce beneficial live bacteria. Consume fermented foods like kefir and sauerkraut, which are particularly beneficial. Berries and dark chocolate support beneficial intestinal bacteria. Reducing processed foods, alcohol, and sugar will help maintain gut health. Intermittent fasting will also help you stay healthy.
  • Adding probiotics. Add inulin and omega-3 fatty acids to your diet. They will help reduce intestinal inflammation and maintain membrane integrity. Don’t forget vitamin D, which is important for immune system function.

Lifestyle adjustments. Stress management practices are essential for health. Exercise and good sleep will ensure mental health. Minimizing exposure to environmental toxins is another important step toward better health.

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Edward Medina
Edward Medina
15:34 30 Jun 22
Just such an amazing staff that makes you feel like part of their family. I’ve been going there for over 5 years now... and each visit I get the very best care and treatments that I have ever received in the 20+ years that I’ve been dealing with severe debilitating migraines. Since i started seeing them the number of my migraines has dropped from 15-20 a month to 2-3 every 3 month. I highly recommend them …they will change your life!read more
Daneisha Johnson
Daneisha Johnson
22:20 19 May 22
Dr. Askari was very kind and explained everything so I could understand. The other staff were nice as well. I would... have gave 5 stars but I was a little taken aback when I checked in and had to pay 600.00 upfront. I think that should have been discussed in a appointment confirmation call or email just so I could have been prepared.read more
Jean Cooper
Jean Cooper
16:54 29 Apr 22
I love the office staff they are friendly and very helpful. Dr. JODIE is very caring and understanding to your needs... and wants to help you. I will go back. would recommend Dr. Dr. Jodie to other Patients in a heart beat. The team works well together.read more
Linda M
Linda M
19:40 02 Apr 22
I was obviously stressed, needing to see a neurologist. The staff was so patient and Dr. Ansari was so kind. At one... point he told me to relax, we have time, when I was relaying my history of my condition. That helped ease my stress. I have seen 3 other neurologists and he was the only one who performed any assessment tests on my cognitive and physical skills. At one point I couldn't complete two assessments and got upset and cried. I was told, it's OK. That's why you're here. I was truly impressed, and super pleased with the whole experience!read more
Leslie Durham
Leslie Durham
15:05 01 Apr 22
I've been coming here for about 5 years. The staff are ALWAYS friendly and knowledgeable. The Doctors are the absolute... best!! Jodie Moore is always in such a great mood which is a plus when you are already stressed. Highly recommendedread more
Monica Del Bosque
Monica Del Bosque
14:13 25 Mar 22
Since my first post my thoughts have changed here. It's unfortunate. My doctor and PA were great, but the office staff... is horrible. They never call you back when they say they will, they misinform you, they cause you too much stress wondering what's going on, they don't keep you posted. They never answer the phone. At this point I've left four messages in the last week, and I have sent three messages. Twice from their portal and one direct email. No response. My appointment is on Monday morning at 8:30am, no confirmation on my insurance and what's going on. What the heck is going on, this is ridiculous!I've given up... the stress her office staff has put me through is just not worth it. You can do so much better, please clean house, either change out your office staff, or find a way for them to be more efficient please. You have to do something. This is not how you want to run your practice. It leaves a very bad impression on your business.read more
Ron Buckholz
Ron Buckholz
23:32 23 Mar 22
I was actually pleasantly surprised with this visit! It took me a long time to get the appointment scheduled because no... one answers your phones EVER! After a month, I finally got in, and your staff was warm, friendly, and I was totally impressed! I feel like you will take care of my needs!read more
Steve Nabavi
Steve Nabavi
16:28 16 Mar 22
It was a nice visit. Happy staff doing all they can do to comfort the patients in a very calming environment. You ask... me they are earned a big gold star on the fridge. My only complaint they didn't give me any cookies.read more
Katie Lewis
Katie Lewis
16:10 10 Feb 22
Had very positive appointments with Jodie and Dr. Sheth for my migraine care. Jodie was so fast with the injections and... has so much valuable info. I started to feel light headed during checkout and the staff was SO helpful—giving me a chair, water, and taking me into a private room until I felt better. Highly recommend this practice for migraine patients, they know what they’re doing!!read more
Joshua Martinez
Joshua Martinez
16:02 10 Dec 21
I was scheduled to be checked and just want to say that the staff was fantastic. They were kind and helpful. I was... asked many questions related to what was going on and not once did I feel as though I was being brushed off. The front desk staff was especially great in assisting me. I'm scheduled to go back for a mri and am glad that I'll be going there.read more
Isabel Ivy
Isabel Ivy
21:42 03 Nov 21
I had such a good experience with Lone Star Neurology, Brent my MRI Tech was so awesome and made sure I was very... comfortable during the appointment. He gave me ear plugs, a pillow, leg support and blanket, easiest MRI ever lol 🤣 My 72 hour EEG nurse Amanda was also so awesome. She made sure I was take care of over the 3 days and took her time with the electrodes to make sure it was comfortable for me! Paige was also a huge help in answering all my questions when it came to my test results, and letting me know her honest opinions about how I should go forth with my treatment.read more
Leslie Luce
Leslie Luce
17:37 20 Oct 21
The professionalism and want to help attitude of this office was present from the moment I contacted them. The follow... up and follow through as well as their willingness to find a way to schedule my dad was above and beyond. We visited two offices in the same day with the same experience. I am appreciative of this—we spend a lot of time with doctors and this was top notch start to finish.read more
robert Parker
robert Parker
16:38 16 Apr 21
I love going to this office. The staff is friendly and helpful. The doctor is great. I am getting the best... neurological tests and treatment I have ever had. The only reason I did not give them a 5 star rating is because it is impossible to reach a live person at the office to reschedule appointments. Every time I have tried to get through to the office it says all people are busy and I am sent to a voicemail. If they could get their phone answering fixed, I would give them a strong 5 stars.read more
MaryAnn Hornbaker
MaryAnn Hornbaker
00:26 25 Feb 21
Dr. Harney is an excellent Dr. I found him friendly , personable and thorough. I evidently am an unusual case. ... Therefore he spent a Hugh amount of time educating me. He even gave me literature to further explain my condition and how to follow up. This is something you rarely get from your doctors. So I am more than please with my doctor and his staff.read more
Roger Arguello
Roger Arguello
03:05 29 Jan 21
Always courteous, professional. The staff is very friendly and always work with you to find the best appointment time.... The care team has been great. Always taking the time to listen to your concerns and to find the best treatment.read more
Margaret Rowland
Margaret Rowland
01:12 27 Jan 21
I have been a patient at Lone Star Neurology for several years. Now both my adult daughters also are patients there. I... love Jodie. She is always so prompt whether it is a teleamed call are a visit in the office. She takes the time to explain everything to me and answers all my questions. I am so blessed to have Jodie as my doctor.read more
Susan Miller
Susan Miller
03:01 13 Jan 21
My husband had an accident 5 years ago and Lone Star Neurology has been such a blessing to us with my husbands care.... Jodie Moore is his provider and she is amazing! Jodie is very knowledgeable, caring, and thorough. She takes her time with you, making sure your needs are met and she is happy to answer any questions you may have. Lone Star Neurology’s patients are very lucky to have Jodie providing their care. Thank you Lone Star Neurology and especially Jodie for everything you have done for us. Jodie, you are the best!read more
Windalyn C
Windalyn C
01:32 09 Jan 21
Jodie is wonderful. She is very caring and knowledgeable. I have been to over a dozen neurologists, and none were able... to help me as much as they have here. Thanks!read more
Katie Kordel
Katie Kordel
00:40 09 Jan 21
Jodi Moore, nurse practitioner, is amazing. I have suffered from frequent, debilitating headaches for almost 20 years.... She has provided the best proactive and responsive care I have ever received. My quality of life has been greatly improved by her caring approach and tenacity in finding solutions.read more
Ellie Natsis
Ellie Natsis
15:41 07 Jan 21
I have had the best experience at this neurologist's office! For over a year I have been receiving iv treatments here... each month and my nurse, Bobbie is beyond wonderful!! She's so attentive, knowledgeable, caring, and detail oriented. She makes an otherwise uncomfortable experience much more pleasant and definitely puts me at ease! She also helps me with my insurance,ordering this specialty medication and dealing with the ordering process which is no easy feat.Needless to say, she goes above a beyond in every way and I'm so grateful to this office and to Bobbie for all they do for me!read more
Matt Morris
Matt Morris
15:39 07 Jan 21
Let me start by saying that I have been coming here for years. Due to my autoimmune disease, I am in this office... once every three weeks for multiple hours at a time. The office is very clean and the staff very friendly. My only complaint would be there communication via phone. They aren't the best at responding if you leave a voicemail and expect a call back. I understand that this is prob just due to the sheer number of alls they receive daily. What I can say I like the best about the office are the people. Bobby who handles my infusions is great. I never have any issues with her setting up my infusions. She is very quick to reply to messages sent via text and if she were to leave then my whole opinion of the office may change. I also enjoy people like Matt, Lauren, and Jodi. I appreciate all that they do for me and without this team I'm not sure I would be as happy as I am to visit the office as frequently as I have to. Please ensure that these folks are recognized as they are what makes my visit to this office so tolerable :).read more
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